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E.Co.Tech-electrochemical handheld breathalyzer COVID sensing technology
Breathomics is widely emerging as a strategy for non-invasive diagnosis of respiratory inflammation. In this study, we have evaluated the metabolic signals associated with Coronavirus (SARS COV-2), mainly the release of nitric oxide in breath. We have demonstrated the utility of a breath analyzer-ba...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919908/ https://www.ncbi.nlm.nih.gov/pubmed/35288614 http://dx.doi.org/10.1038/s41598-022-08321-x |
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author | Banga, Ivneet Paul, Anirban France, Kordel Micklich, Ben Cardwell, Bret Micklich, Craig Prasad, Shalini |
author_facet | Banga, Ivneet Paul, Anirban France, Kordel Micklich, Ben Cardwell, Bret Micklich, Craig Prasad, Shalini |
author_sort | Banga, Ivneet |
collection | PubMed |
description | Breathomics is widely emerging as a strategy for non-invasive diagnosis of respiratory inflammation. In this study, we have evaluated the metabolic signals associated with Coronavirus (SARS COV-2), mainly the release of nitric oxide in breath. We have demonstrated the utility of a breath analyzer-based sensor platform for the detection of trace amounts of this target species. The sensor surface is modified with Room Temperature Ionic Liquid (RTIL) that allows faster diffusion of the target gas and can be used for gas sensing application. A low limit of detection (LOD) of 50 parts per billion has been achieved with a 95% confidence interval for detection of nitric oxide.. This inhouse designed sensor is incorporated into a breath analyzer system that displays enhanced sensitivity, specificity, linearity, and reproducibility for NO gas monitoring. The developed sensor platform can detect target concentrations of NO ranging from 50 to 250 ppb, using 1-Ethyl-3-methylimidazolium Tetrafluoroborate ([EMIM]BF(4)) as RTIL and displays fast response time of 5 s, thereby allowing easy detection of the target gas species. The sensor successfully quantifies the diffusion current and charge modulations arising within the electrical double layer from the RTIL–NO interactions through DC-based chronoamperometry (CA). The subjects tested negative and positive are significantly different (p < 0.01). The prototype can potentially be used for human health monitoring and screening, especially during the pandemic due to its portability, small size, an embedded RTIL sensing element, integrability with a low-power microelectronic device, and an IoT interface. |
format | Online Article Text |
id | pubmed-8919908 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-89199082022-03-15 E.Co.Tech-electrochemical handheld breathalyzer COVID sensing technology Banga, Ivneet Paul, Anirban France, Kordel Micklich, Ben Cardwell, Bret Micklich, Craig Prasad, Shalini Sci Rep Article Breathomics is widely emerging as a strategy for non-invasive diagnosis of respiratory inflammation. In this study, we have evaluated the metabolic signals associated with Coronavirus (SARS COV-2), mainly the release of nitric oxide in breath. We have demonstrated the utility of a breath analyzer-based sensor platform for the detection of trace amounts of this target species. The sensor surface is modified with Room Temperature Ionic Liquid (RTIL) that allows faster diffusion of the target gas and can be used for gas sensing application. A low limit of detection (LOD) of 50 parts per billion has been achieved with a 95% confidence interval for detection of nitric oxide.. This inhouse designed sensor is incorporated into a breath analyzer system that displays enhanced sensitivity, specificity, linearity, and reproducibility for NO gas monitoring. The developed sensor platform can detect target concentrations of NO ranging from 50 to 250 ppb, using 1-Ethyl-3-methylimidazolium Tetrafluoroborate ([EMIM]BF(4)) as RTIL and displays fast response time of 5 s, thereby allowing easy detection of the target gas species. The sensor successfully quantifies the diffusion current and charge modulations arising within the electrical double layer from the RTIL–NO interactions through DC-based chronoamperometry (CA). The subjects tested negative and positive are significantly different (p < 0.01). The prototype can potentially be used for human health monitoring and screening, especially during the pandemic due to its portability, small size, an embedded RTIL sensing element, integrability with a low-power microelectronic device, and an IoT interface. Nature Publishing Group UK 2022-03-14 /pmc/articles/PMC8919908/ /pubmed/35288614 http://dx.doi.org/10.1038/s41598-022-08321-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Banga, Ivneet Paul, Anirban France, Kordel Micklich, Ben Cardwell, Bret Micklich, Craig Prasad, Shalini E.Co.Tech-electrochemical handheld breathalyzer COVID sensing technology |
title | E.Co.Tech-electrochemical handheld breathalyzer COVID sensing technology |
title_full | E.Co.Tech-electrochemical handheld breathalyzer COVID sensing technology |
title_fullStr | E.Co.Tech-electrochemical handheld breathalyzer COVID sensing technology |
title_full_unstemmed | E.Co.Tech-electrochemical handheld breathalyzer COVID sensing technology |
title_short | E.Co.Tech-electrochemical handheld breathalyzer COVID sensing technology |
title_sort | e.co.tech-electrochemical handheld breathalyzer covid sensing technology |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919908/ https://www.ncbi.nlm.nih.gov/pubmed/35288614 http://dx.doi.org/10.1038/s41598-022-08321-x |
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