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Clinical Presentations and Outcomes of Children in Canada With Recurrent Invasive Pneumococcal Disease From the IMPACT Surveillance Network
Invasive pneumococcal disease due to Streptococcus pneumoniae can cause mortality and severe morbidity due to sepsis, meningitis and pneumonia, particularly in young children and the elderly. Recurrent invasive pneumococcal disease is rare yet serious sequelae of invasive pneumococcal disease that i...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920017/ https://www.ncbi.nlm.nih.gov/pubmed/35093996 http://dx.doi.org/10.1097/INF.0000000000003454 |
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author | Murad, Yousif Hung, Te-Yu Sadarangani, Manish Morris, Shaun K. Le Saux, Nicole Vanderkooi, Otto G. Kellner, James D. Tyrrell, Gregory J. Martin, Irene Demczuk, Walter Halperin, Scott A. Bettinger, Julie A. Bridger, N. Foo, Cheryl Halperin, S.A. Top, K.A. Thibeault, R. Moore, D. Papenburg, J. Lebel, M. Le Saux, N. Morris, S. Embree, J. Tan, B. McConnell, Athena Jadavji, T. Constantinescu, C. Vaudry, W. Scheifele, D. Sadarangani, M. Bettinger, J. Sauvé, L. |
author_facet | Murad, Yousif Hung, Te-Yu Sadarangani, Manish Morris, Shaun K. Le Saux, Nicole Vanderkooi, Otto G. Kellner, James D. Tyrrell, Gregory J. Martin, Irene Demczuk, Walter Halperin, Scott A. Bettinger, Julie A. Bridger, N. Foo, Cheryl Halperin, S.A. Top, K.A. Thibeault, R. Moore, D. Papenburg, J. Lebel, M. Le Saux, N. Morris, S. Embree, J. Tan, B. McConnell, Athena Jadavji, T. Constantinescu, C. Vaudry, W. Scheifele, D. Sadarangani, M. Bettinger, J. Sauvé, L. |
author_sort | Murad, Yousif |
collection | PubMed |
description | Invasive pneumococcal disease due to Streptococcus pneumoniae can cause mortality and severe morbidity due to sepsis, meningitis and pneumonia, particularly in young children and the elderly. Recurrent invasive pneumococcal disease is rare yet serious sequelae of invasive pneumococcal disease that is associated with the immunocompromised and leads to a high mortality rate. METHOD: This retrospective study reviewed recurrent invasive pneumococcal disease cases from the Canadian Immunization Monitoring Program, ACTive (IMPACT) between 1991 and 2019, an active network for surveillance of vaccine-preventable diseases and adverse events following immunization for children ages 0–16 years. Data were collected from 12 pediatric tertiary care hospitals across all 3 eras of public pneumococcal conjugate vaccine implementation in Canada. RESULTS: The survival rate within our cohort of 180 recurrent invasive pneumococcal disease cases was 98.3%. A decrease of 26.4% in recurrent invasive pneumococcal disease due to vaccine serotypes was observed with pneumococcal vaccine introduction. There was also a 69.0% increase in the rate of vaccination in children with preexisting medical conditions compared with their healthy peers. CONCLUSION: The decrease in recurrent invasive pneumococcal disease due to vaccine-covered serotypes has been offset by an increase of non-vaccine serotypes in this sample of Canadian children. |
format | Online Article Text |
id | pubmed-8920017 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-89200172022-03-18 Clinical Presentations and Outcomes of Children in Canada With Recurrent Invasive Pneumococcal Disease From the IMPACT Surveillance Network Murad, Yousif Hung, Te-Yu Sadarangani, Manish Morris, Shaun K. Le Saux, Nicole Vanderkooi, Otto G. Kellner, James D. Tyrrell, Gregory J. Martin, Irene Demczuk, Walter Halperin, Scott A. Bettinger, Julie A. Bridger, N. Foo, Cheryl Halperin, S.A. Top, K.A. Thibeault, R. Moore, D. Papenburg, J. Lebel, M. Le Saux, N. Morris, S. Embree, J. Tan, B. McConnell, Athena Jadavji, T. Constantinescu, C. Vaudry, W. Scheifele, D. Sadarangani, M. Bettinger, J. Sauvé, L. Pediatr Infect Dis J Vaccine Reports Invasive pneumococcal disease due to Streptococcus pneumoniae can cause mortality and severe morbidity due to sepsis, meningitis and pneumonia, particularly in young children and the elderly. Recurrent invasive pneumococcal disease is rare yet serious sequelae of invasive pneumococcal disease that is associated with the immunocompromised and leads to a high mortality rate. METHOD: This retrospective study reviewed recurrent invasive pneumococcal disease cases from the Canadian Immunization Monitoring Program, ACTive (IMPACT) between 1991 and 2019, an active network for surveillance of vaccine-preventable diseases and adverse events following immunization for children ages 0–16 years. Data were collected from 12 pediatric tertiary care hospitals across all 3 eras of public pneumococcal conjugate vaccine implementation in Canada. RESULTS: The survival rate within our cohort of 180 recurrent invasive pneumococcal disease cases was 98.3%. A decrease of 26.4% in recurrent invasive pneumococcal disease due to vaccine serotypes was observed with pneumococcal vaccine introduction. There was also a 69.0% increase in the rate of vaccination in children with preexisting medical conditions compared with their healthy peers. CONCLUSION: The decrease in recurrent invasive pneumococcal disease due to vaccine-covered serotypes has been offset by an increase of non-vaccine serotypes in this sample of Canadian children. Lippincott Williams & Wilkins 2022-03-04 2022-04 /pmc/articles/PMC8920017/ /pubmed/35093996 http://dx.doi.org/10.1097/INF.0000000000003454 Text en Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Vaccine Reports Murad, Yousif Hung, Te-Yu Sadarangani, Manish Morris, Shaun K. Le Saux, Nicole Vanderkooi, Otto G. Kellner, James D. Tyrrell, Gregory J. Martin, Irene Demczuk, Walter Halperin, Scott A. Bettinger, Julie A. Bridger, N. Foo, Cheryl Halperin, S.A. Top, K.A. Thibeault, R. Moore, D. Papenburg, J. Lebel, M. Le Saux, N. Morris, S. Embree, J. Tan, B. McConnell, Athena Jadavji, T. Constantinescu, C. Vaudry, W. Scheifele, D. Sadarangani, M. Bettinger, J. Sauvé, L. Clinical Presentations and Outcomes of Children in Canada With Recurrent Invasive Pneumococcal Disease From the IMPACT Surveillance Network |
title | Clinical Presentations and Outcomes of Children in Canada With Recurrent Invasive Pneumococcal Disease From the IMPACT Surveillance Network |
title_full | Clinical Presentations and Outcomes of Children in Canada With Recurrent Invasive Pneumococcal Disease From the IMPACT Surveillance Network |
title_fullStr | Clinical Presentations and Outcomes of Children in Canada With Recurrent Invasive Pneumococcal Disease From the IMPACT Surveillance Network |
title_full_unstemmed | Clinical Presentations and Outcomes of Children in Canada With Recurrent Invasive Pneumococcal Disease From the IMPACT Surveillance Network |
title_short | Clinical Presentations and Outcomes of Children in Canada With Recurrent Invasive Pneumococcal Disease From the IMPACT Surveillance Network |
title_sort | clinical presentations and outcomes of children in canada with recurrent invasive pneumococcal disease from the impact surveillance network |
topic | Vaccine Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920017/ https://www.ncbi.nlm.nih.gov/pubmed/35093996 http://dx.doi.org/10.1097/INF.0000000000003454 |
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