Design of SARS-CoV-2 Mpro, PLpro dual-target inhibitors based on deep reinforcement learning and virtual screening

Background: Since December 2019, SARS-CoV-2 has continued to spread rapidly around the world. The effective drugs may provide a long-term strategy to combat this virus. The main protease (Mpro) and papain-like protease (PLpro) are two important targets for the inhibition of SARS-CoV-2 virus replicat...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Li-chuan, Zhao, Hui-lin, Liu, Jin, He, Lei, Yu, Ri-lei, Kang, Cong-min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Newlands Press Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920029/
https://www.ncbi.nlm.nih.gov/pubmed/35220726
http://dx.doi.org/10.4155/fmc-2021-0269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920029/
https://www.ncbi.nlm.nih.gov/pubmed/35220726
http://dx.doi.org/10.4155/fmc-2021-0269

Ejemplares similares