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Design of SARS-CoV-2 Mpro, PLpro dual-target inhibitors based on deep reinforcement learning and virtual screening

Background: Since December 2019, SARS-CoV-2 has continued to spread rapidly around the world. The effective drugs may provide a long-term strategy to combat this virus. The main protease (Mpro) and papain-like protease (PLpro) are two important targets for the inhibition of SARS-CoV-2 virus replicat...

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Detalles Bibliográficos
Autores principales:	Zhang, Li-chuan, Zhao, Hui-lin, Liu, Jin, He, Lei, Yu, Ri-lei, Kang, Cong-min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Newlands Press Ltd 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920029/ https://www.ncbi.nlm.nih.gov/pubmed/35220726 http://dx.doi.org/10.4155/fmc-2021-0269

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