Loss of m(6)A Methyltransferase METTL5 Promotes Cardiac Hypertrophy Through Epitranscriptomic Control of SUZ12 Expression

Enhancement of protein synthesis from mRNA translation is one of the key steps supporting cardiomyocyte hypertrophy during cardiac remodeling. The methyltransferase-like5 (METTL5), which catalyzes m(6)A modification of 18S rRNA at position A(1832), has been shown to regulate the efficiency of mRNA t...

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Detalles Bibliográficos
Autores principales: Han, Yanchuang, Du, Tailai, Guo, Siyao, Wang, Lu, Dai, Gang, Long, Tianxin, Xu, Ting, Zhuang, Xiaodong, Liu, Chen, Li, Shujuan, Zhang, Dihua, Liao, Xinxue, Dong, Yugang, Lui, Kathy O., Tan, Xu, Lin, Shuibin, Chen, Yili, Huang, Zhan-Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920042/
https://www.ncbi.nlm.nih.gov/pubmed/35295259
http://dx.doi.org/10.3389/fcvm.2022.852775

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