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Prediction of hERG inhibition of drug discovery compounds using biomimetic HPLC measurements
The major causes of failure of drug discovery compounds in clinics are the lack of efficacy and toxicity. To reduce late-stage failures in the drug discovery process, it is essential to estimate early the probability of adverse effects and potential toxicity. Cardiotoxicity is one of the most often...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
International Association of Physical Chemists
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920097/ https://www.ncbi.nlm.nih.gov/pubmed/35300361 http://dx.doi.org/10.5599/admet.995 |