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Epidemiological characteristics and trends of Bacillus Calmette–Guérin lymphadenitis in Shanghai, China from 2010 to 2019

Although the administration of the Bacillus Calmette–Guérin (BCG) vaccine is generally safe, lymphadenitis, the most common complication of BCG vaccination, can occur. Here, we describe the epidemiological characteristics and incidence trends of BCG lymphadenitis in Shanghai, China, among a populati...

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Autores principales: Wang, Jing, Zhou, Feng, Jiang, Ming-Bo, Xu, Zhen-hui, Ni, Yi-hong, Wu, Qiang-Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920159/
https://www.ncbi.nlm.nih.gov/pubmed/34156902
http://dx.doi.org/10.1080/21645515.2021.1938922
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author Wang, Jing
Zhou, Feng
Jiang, Ming-Bo
Xu, Zhen-hui
Ni, Yi-hong
Wu, Qiang-Song
author_facet Wang, Jing
Zhou, Feng
Jiang, Ming-Bo
Xu, Zhen-hui
Ni, Yi-hong
Wu, Qiang-Song
author_sort Wang, Jing
collection PubMed
description Although the administration of the Bacillus Calmette–Guérin (BCG) vaccine is generally safe, lymphadenitis, the most common complication of BCG vaccination, can occur. Here, we describe the epidemiological characteristics and incidence trends of BCG lymphadenitis in Shanghai, China, among a population with a high burden of tuberculosis. A total of 56 cases of adverse events following immunization (AEFI) after BCG vaccination were reported in Shanghai, including 51 cases of BCG lymphadenitis (91.07%), from 2010 to 2019. The general incidence of BCG lymphadenitis was 173 per 1,000,000 doses in Shanghai from 2010 to 2019. A nonsignificant increase of 58.81% per year was observed between 2010 and 2012 (t = 0.93; p = .40), followed by a significant decline of 28.00% per year from 2012 to 2019 (t = −4.27; p < .01). Seven batches of BCG vaccines triggered three or more BCG lymphadenitis cases, for 27 (52.94%) cases in total. We identified two patients with immunodeficiency of chronic granulomatous disease, one of whom died four years later after BCG vaccination and another of whom was still being treated after two transplants. The average total care cost of the 47 recovered cases was 11,336 RMB (range: 2,637–33,861 RMB). Due to the high burden of BCG lymphadenitis, especially in children with immunodeficiency, it is suggested that government departments should strengthen healthcare provider training, assign specific nurses to perform BCG vaccination, monitor vaccinated individuals actively and timely detect abnormal signals so as to reduce the incidence of BCG lymphadenitis.
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spelling pubmed-89201592022-03-15 Epidemiological characteristics and trends of Bacillus Calmette–Guérin lymphadenitis in Shanghai, China from 2010 to 2019 Wang, Jing Zhou, Feng Jiang, Ming-Bo Xu, Zhen-hui Ni, Yi-hong Wu, Qiang-Song Hum Vaccin Immunother Licensed Vaccines – Research Paper Although the administration of the Bacillus Calmette–Guérin (BCG) vaccine is generally safe, lymphadenitis, the most common complication of BCG vaccination, can occur. Here, we describe the epidemiological characteristics and incidence trends of BCG lymphadenitis in Shanghai, China, among a population with a high burden of tuberculosis. A total of 56 cases of adverse events following immunization (AEFI) after BCG vaccination were reported in Shanghai, including 51 cases of BCG lymphadenitis (91.07%), from 2010 to 2019. The general incidence of BCG lymphadenitis was 173 per 1,000,000 doses in Shanghai from 2010 to 2019. A nonsignificant increase of 58.81% per year was observed between 2010 and 2012 (t = 0.93; p = .40), followed by a significant decline of 28.00% per year from 2012 to 2019 (t = −4.27; p < .01). Seven batches of BCG vaccines triggered three or more BCG lymphadenitis cases, for 27 (52.94%) cases in total. We identified two patients with immunodeficiency of chronic granulomatous disease, one of whom died four years later after BCG vaccination and another of whom was still being treated after two transplants. The average total care cost of the 47 recovered cases was 11,336 RMB (range: 2,637–33,861 RMB). Due to the high burden of BCG lymphadenitis, especially in children with immunodeficiency, it is suggested that government departments should strengthen healthcare provider training, assign specific nurses to perform BCG vaccination, monitor vaccinated individuals actively and timely detect abnormal signals so as to reduce the incidence of BCG lymphadenitis. Taylor & Francis 2021-06-22 /pmc/articles/PMC8920159/ /pubmed/34156902 http://dx.doi.org/10.1080/21645515.2021.1938922 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Licensed Vaccines – Research Paper
Wang, Jing
Zhou, Feng
Jiang, Ming-Bo
Xu, Zhen-hui
Ni, Yi-hong
Wu, Qiang-Song
Epidemiological characteristics and trends of Bacillus Calmette–Guérin lymphadenitis in Shanghai, China from 2010 to 2019
title Epidemiological characteristics and trends of Bacillus Calmette–Guérin lymphadenitis in Shanghai, China from 2010 to 2019
title_full Epidemiological characteristics and trends of Bacillus Calmette–Guérin lymphadenitis in Shanghai, China from 2010 to 2019
title_fullStr Epidemiological characteristics and trends of Bacillus Calmette–Guérin lymphadenitis in Shanghai, China from 2010 to 2019
title_full_unstemmed Epidemiological characteristics and trends of Bacillus Calmette–Guérin lymphadenitis in Shanghai, China from 2010 to 2019
title_short Epidemiological characteristics and trends of Bacillus Calmette–Guérin lymphadenitis in Shanghai, China from 2010 to 2019
title_sort epidemiological characteristics and trends of bacillus calmette–guérin lymphadenitis in shanghai, china from 2010 to 2019
topic Licensed Vaccines – Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920159/
https://www.ncbi.nlm.nih.gov/pubmed/34156902
http://dx.doi.org/10.1080/21645515.2021.1938922
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