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Novel mutation in hexokinase 2 confers resistance to 2-deoxyglucose by altering protein dynamics

Glucose is central to many biological processes, serving as an energy source and a building block for biosynthesis. After glucose enters the cell, hexokinases convert it to glucose-6-phosphate (Glc-6P) for use in anaerobic fermentation, aerobic oxidative phosphorylation, and the pentose-phosphate pa...

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Detalles Bibliográficos
Autores principales:	Hellemann, Erich, Walker, Jennifer L., Lesko, Mitchell A., Chandrashekarappa, Dakshayini G., Schmidt, Martin C., O’Donnell, Allyson F., Durrant, Jacob D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920189/ https://www.ncbi.nlm.nih.gov/pubmed/35235554 http://dx.doi.org/10.1371/journal.pcbi.1009929

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