Kynurenine-3-monooxygenase (KMO) broadly inhibits viral infections via triggering NMDAR/Ca(2+) influx and CaMKII/ IRF3-mediated IFN-β production

Tryptophan (Trp) metabolism through the kynurenine pathway (KP) is well known to play a critical function in cancer, autoimmune and neurodegenerative diseases. However, its role in host-pathogen interactions has not been characterized yet. Herein, we identified that kynurenine-3-monooxygenase (KMO),...

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Detalles Bibliográficos
Autores principales: Zhao, Jin, Chen, Jiaoshan, Wang, Congcong, Liu, Yajie, Li, Minchao, Li, Yanjun, Li, Ruiting, Han, Zirong, Wang, Junjian, Chen, Ling, Shu, Yuelong, Cheng, Genhong, Sun, Caijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920235/
https://www.ncbi.nlm.nih.gov/pubmed/35235615
http://dx.doi.org/10.1371/journal.ppat.1010366

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