Cargando…

Evaluation of processing mechanism in Astragali Radix by low-field nuclear magnetic resonance and magnetic resonance imaging

Astragali Radix (Huangqi) is an important herb medicine that is always processed into pieces for clinical use. Many operations need to be performed before use, among which drying of Astragali Radix (AR) pieces is a key step. Unfortunately, research on its drying mechanism is still limited. Low-field...

Descripción completa

Detalles Bibliográficos
Autores principales: Peng, Jie, Ye, Lifang, Wu, Mengmei, Wu, Menghua, Ma, Zhiguo, Cao, Hui, Zhang, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920280/
https://www.ncbi.nlm.nih.gov/pubmed/35286357
http://dx.doi.org/10.1371/journal.pone.0265383
_version_ 1784669094226690048
author Peng, Jie
Ye, Lifang
Wu, Mengmei
Wu, Menghua
Ma, Zhiguo
Cao, Hui
Zhang, Ying
author_facet Peng, Jie
Ye, Lifang
Wu, Mengmei
Wu, Menghua
Ma, Zhiguo
Cao, Hui
Zhang, Ying
author_sort Peng, Jie
collection PubMed
description Astragali Radix (Huangqi) is an important herb medicine that is always processed into pieces for clinical use. Many operations need to be performed before use, among which drying of Astragali Radix (AR) pieces is a key step. Unfortunately, research on its drying mechanism is still limited. Low-field nuclear magnetic resonance (LF-NMR) and magnetic resonance imaging (MRI) techniques were applied to study the moisture state and distribution during drying. The content of bioactive components and texture changes were measured by HPLC and texture analyzer, respectively. The moisture content of the AR pieces decreased significantly during drying, and the time to reach the drying equilibrium were different at different temperatures. The time when at 70°C, 80°C, and 90°C reach complete drying are 180 min, 150 min and 120 min, respectively. 80°C was determined as the optimum drying temperature, and it was observed that the four flavonoids and astragaloside IV have some thermal stability in AR pieces. When dried at 80°C, although the total water content decreased, the free water content decreased from 99.38% to 15.49%, in contrast to the increase in bound water content from 0.62% to 84.51%. The texture parameters such as hardness changed to some extent, with the hardness rising most significantly from 686.23 g to 2656.67 g. Correlation analysis revealed some connection between moisture content and LF-NMR and texture analyzer parameters, but the springiness did not show a clear correlation with most parameters. This study shows that HPLC, LF-NMR, MRI, and texture analyzers provide a scientific basis for elucidating the drying principles of AR pieces. The method is useful and shows potential for extension and application; therefore, it can be easily extended to other natural herb medicines.
format Online
Article
Text
id pubmed-8920280
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-89202802022-03-15 Evaluation of processing mechanism in Astragali Radix by low-field nuclear magnetic resonance and magnetic resonance imaging Peng, Jie Ye, Lifang Wu, Mengmei Wu, Menghua Ma, Zhiguo Cao, Hui Zhang, Ying PLoS One Research Article Astragali Radix (Huangqi) is an important herb medicine that is always processed into pieces for clinical use. Many operations need to be performed before use, among which drying of Astragali Radix (AR) pieces is a key step. Unfortunately, research on its drying mechanism is still limited. Low-field nuclear magnetic resonance (LF-NMR) and magnetic resonance imaging (MRI) techniques were applied to study the moisture state and distribution during drying. The content of bioactive components and texture changes were measured by HPLC and texture analyzer, respectively. The moisture content of the AR pieces decreased significantly during drying, and the time to reach the drying equilibrium were different at different temperatures. The time when at 70°C, 80°C, and 90°C reach complete drying are 180 min, 150 min and 120 min, respectively. 80°C was determined as the optimum drying temperature, and it was observed that the four flavonoids and astragaloside IV have some thermal stability in AR pieces. When dried at 80°C, although the total water content decreased, the free water content decreased from 99.38% to 15.49%, in contrast to the increase in bound water content from 0.62% to 84.51%. The texture parameters such as hardness changed to some extent, with the hardness rising most significantly from 686.23 g to 2656.67 g. Correlation analysis revealed some connection between moisture content and LF-NMR and texture analyzer parameters, but the springiness did not show a clear correlation with most parameters. This study shows that HPLC, LF-NMR, MRI, and texture analyzers provide a scientific basis for elucidating the drying principles of AR pieces. The method is useful and shows potential for extension and application; therefore, it can be easily extended to other natural herb medicines. Public Library of Science 2022-03-14 /pmc/articles/PMC8920280/ /pubmed/35286357 http://dx.doi.org/10.1371/journal.pone.0265383 Text en © 2022 Peng et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Peng, Jie
Ye, Lifang
Wu, Mengmei
Wu, Menghua
Ma, Zhiguo
Cao, Hui
Zhang, Ying
Evaluation of processing mechanism in Astragali Radix by low-field nuclear magnetic resonance and magnetic resonance imaging
title Evaluation of processing mechanism in Astragali Radix by low-field nuclear magnetic resonance and magnetic resonance imaging
title_full Evaluation of processing mechanism in Astragali Radix by low-field nuclear magnetic resonance and magnetic resonance imaging
title_fullStr Evaluation of processing mechanism in Astragali Radix by low-field nuclear magnetic resonance and magnetic resonance imaging
title_full_unstemmed Evaluation of processing mechanism in Astragali Radix by low-field nuclear magnetic resonance and magnetic resonance imaging
title_short Evaluation of processing mechanism in Astragali Radix by low-field nuclear magnetic resonance and magnetic resonance imaging
title_sort evaluation of processing mechanism in astragali radix by low-field nuclear magnetic resonance and magnetic resonance imaging
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920280/
https://www.ncbi.nlm.nih.gov/pubmed/35286357
http://dx.doi.org/10.1371/journal.pone.0265383
work_keys_str_mv AT pengjie evaluationofprocessingmechanisminastragaliradixbylowfieldnuclearmagneticresonanceandmagneticresonanceimaging
AT yelifang evaluationofprocessingmechanisminastragaliradixbylowfieldnuclearmagneticresonanceandmagneticresonanceimaging
AT wumengmei evaluationofprocessingmechanisminastragaliradixbylowfieldnuclearmagneticresonanceandmagneticresonanceimaging
AT wumenghua evaluationofprocessingmechanisminastragaliradixbylowfieldnuclearmagneticresonanceandmagneticresonanceimaging
AT mazhiguo evaluationofprocessingmechanisminastragaliradixbylowfieldnuclearmagneticresonanceandmagneticresonanceimaging
AT caohui evaluationofprocessingmechanisminastragaliradixbylowfieldnuclearmagneticresonanceandmagneticresonanceimaging
AT zhangying evaluationofprocessingmechanisminastragaliradixbylowfieldnuclearmagneticresonanceandmagneticresonanceimaging