Lysosomal exocytosis of HSP70 stimulates monocytic BMP6 expression in Sjögren’s syndrome

BMP6 is a central cytokine in the induction of Sjögren’s syndrome–associated (SS-associated) secretory hypofunction. However, the upstream initiation leading to the production of this cytokine in SS is unknown. In this study, RNA ISH on salivary gland sections taken from patients with SS indicated m...

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Detalles Bibliográficos
Autores principales: Mo, Ying-Qian, Nakamura, Hiroyuki, Tanaka, Tsutomu, Odani, Toshio, Perez, Paola, Ji, Youngmi, French, Benjamin N., Pranzatelli, Thomas J.F., Michael, Drew G., Yin, Hongen, Chow, Susan S., Khalaj, Maryam, Afione, Sandra A., Zheng, Changyu, Oliveira, Fabiola Reis, Motta, Ana Carolina F., Ribeiro-Silva, Alfredo, Rocha, Eduardo M., Nguyen, Cuong Q., Noguchi, Masayuki, Atsumi, Tatsuya, Warner, Blake M., Chiorini, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920330/
https://www.ncbi.nlm.nih.gov/pubmed/35113815
http://dx.doi.org/10.1172/JCI152780

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