A CGA/EGFR/GATA2 positive feedback circuit confers chemoresistance in gastric cancer

De novo and acquired resistance are major impediments to the efficacy of conventional and targeted cancer therapy. In unselected gastric cancer (GC) patients with advanced disease, trials combining chemotherapy and an anti-EGFR monoclonal antibody have been largely unsuccessful. In an effort to iden...

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Detalles Bibliográficos
Autores principales: Cao, Tianyu, Lu, Yuanyuan, Wang, Qi, Qin, Hongqiang, Li, Hongwei, Guo, Hao, Ge, Minghui, Glass, Sarah E., Singh, Bhuminder, Zhang, Wenyao, Dong, Jiaqiang, Du, Feng, Qian, Airong, Tian, Ye, Wang, Xin, Li, Cunxi, Wu, Kaichun, Fan, Daiming, Nie, Yongzhan, Coffey, Robert J., Zhao, Xiaodi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920335/
https://www.ncbi.nlm.nih.gov/pubmed/35289315
http://dx.doi.org/10.1172/JCI154074

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