Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors

New approaches for the management of glioblastoma (GBM) are an urgent and unmet clinical need. Here, we illustrate that the efficacy of radiotherapy for GBM is strikingly potentiated by concomitant therapy with the arginine-depleting agent ADI-PEG20 in a non-arginine-auxotrophic cellular background...

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Detalles Bibliográficos
Autores principales: Hajji, Nabil, Garcia-Revilla, Juan, Soto, Manuel Sarmiento, Perryman, Richard, Symington, Jake, Quarles, Chad C., Healey, Deborah R., Guo, Yijie, Orta-Vázquez, Manuel Luis, Mateos-Cordero, Santiago, Shah, Khalid, Bomalaski, John, Anichini, Giulio, Tzakos, Andreas G., Crook, Timothy, O’Neill, Kevin, Scheck, Adrienne C., Venero, Jose Luis, Syed, Nelofer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920336/
https://www.ncbi.nlm.nih.gov/pubmed/35113813
http://dx.doi.org/10.1172/JCI142137

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