An Asia-specific variant of human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment

Emerging studies have focused on ways to treat cancers by modulating T cell activation. However, whether B cell receptor signaling in the tumor microenvironment (TME) can be harnessed for immunotherapy is unclear. Here, we report that an Asia-specific variant of human IgG1 containing a Gly396 to Arg...

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Detalles Bibliográficos
Autores principales: Yang, Bing, Zhang, Zhen, Chen, Xiangjun, Wang, Xu-Yan, Qin, Shishang, Du, Liaoqi, Yang, Changjiang, Zhu, Liyu, Sun, Wenbo, Zhu, Yongjie, Zheng, Qinwen, Zhao, Shidong, Wang, Quan, Zhao, Long, Lin, Yilin, Huang, Jinghe, Wu, Fan, Lu, Lu, Wang, Fei, Zheng, Wenjie, Zhou, Xiao-Hua, Zhao, Xiaozhen, Wang, Ziye, Xiao-Lin, Sun, Ye, Yingjiang, Wang, Shan, Li, Zhanguo, Qi, Hai, Zhang, Zemin, Kuang, Dong-Ming, Zhang, Lei, Shen, Zhanlong, Liu, Wanli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920342/
https://www.ncbi.nlm.nih.gov/pubmed/35133976
http://dx.doi.org/10.1172/JCI153454

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