Cargando…

Ipriflavone as a non‐steroidal glucocorticoid receptor antagonist ameliorates diabetic cognitive impairment in mice

Diabetic cognitive impairment (DCI) is a common diabetic complication with hallmarks of loss of learning ability and disorders of memory and behavior. Glucocorticoid receptor (GR) dysfunction is a main reason for neuronal impairment in brain of diabetic patients. Here, we determined that ipriflavone...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nie, Ruifang, Lu, Jian, Xu, Rui, Yang, Juanzhen, Shen, Xingyi, Ouyang, Xingnan, Zhu, Danyang, Huang, Yujie, Zhao, Tong, Zhao, Xuejian, Lu, Yin, Qian, Minyi, Wang, Jiaying, Shen, Xu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920458/ https://www.ncbi.nlm.nih.gov/pubmed/35172041 http://dx.doi.org/10.1111/acel.13572

Ejemplares similares

FX5, a non-steroidal glucocorticoid receptor antagonist, ameliorates diabetic cognitive impairment in mice
por: Zhu, Dan-yang, et al.
Publicado: (2022)

Ipriflavone and Ipriflavone loaded albumin nanoparticles reverse lipopolysaccharide induced neuroinflammation in rats
por: Yassa, Nashwa W., et al.
Publicado: (2020)

Retraction: Ipriflavone and Ipriflavone loaded albumin nanoparticles reverse lipopolysaccharide induced neuroinflammation in rats
Publicado: (2023)

Miltefosine as a PPM1A activator improves AD-like pathology in mice by alleviating tauopathy via microglia/neurons crosstalk
por: Lv, Jianlu, et al.
Publicado: (2022)

Ipriflavone attenuates the degeneration of cartilage by blocking the Indian hedgehog pathway
por: Guo, Li, et al.
Publicado: (2019)

Ipriflavone-Loaded Mesoporous Nanospheres with Potential Applications for Periodontal Treatment
por: Casarrubios, Laura, et al.
Publicado: (2020)

Antispasmodic Drug Drofenine as an Inhibitor of Kv2.1 Channel Ameliorates Peripheral Neuropathy in Diabetic Mice
por: Xu, Xiaoju, et al.
Publicado: (2020)

FX5 as a non-steroidal GR antagonist improved glucose homeostasis in type 2 diabetic mice via GR/HNF4α/miR-122-5p pathway
por: Xu, Xin, et al.
Publicado: (2020)

Effects of Ipriflavone-Loaded Mesoporous Nanospheres on the Differentiation of Endothelial Progenitor Cells and Their Modulation by Macrophages
por: Casarrubios, Laura, et al.
Publicado: (2021)

Development of Therapeutic Agent for Osteoarthritis via Inhibition of KIAA1199 Activity: Effect of Ipriflavone In Vivo
por: Zhang, Jiarui, et al.
Publicado: (2023)

Ipriflavone Suppresses Growth of Esophageal Squamous Cell Carcinoma Through Inhibiting mTOR In Vitro and In Vivo
por: Shi, Xiaodan, et al.
Publicado: (2021)

Antiallergic drug desloratadine as a selective antagonist of 5HT(2A) receptor ameliorates pathology of Alzheimer's disease model mice by improving microglial dysfunction
por: Lu, Jian, et al.
Publicado: (2020)

Ipriflavone promotes proliferation and osteogenic differentiation of periodontal ligament cells by activating GPR30/PI3K/AKT signaling pathway
por: Han, Yuanyuan, et al.
Publicado: (2018)

Inhibition of glucocorticoid-induced alteration of vimentin by a glucocorticoid receptor antagonist RU486 in the organ-cultured rat lens
por: Xie, Guo-Li, et al.
Publicado: (2011)

Possible Repositioning of an Oral Anti-Osteoporotic Drug, Ipriflavone, for Treatment of Inflammatory Arthritis via Inhibitory Activity of KIAA1199, a Novel Potent Hyaluronidase
por: Koike, Hiroshi, et al.
Publicado: (2022)

Impaired anti-inflammatory action of glucocorticoid in neutrophil from patients with steroid-resistant asthma
por: Wang, Meijia, et al.
Publicado: (2016)

S1PR2 antagonist ameliorate high glucose-induced fission and dysfunction of mitochondria in HRGECs via regulating ROCK1
por: Chen, Wei, et al.
Publicado: (2019)

Steroidal and non-steroidal mineralocorticoid receptor antagonists in cardiorenal medicine
por: Agarwal, Rajiv, et al.
Publicado: (2020)

Let-7f-5p regulates TGFBR1 in glucocorticoid-inhibited osteoblast differentiation and ameliorates glucocorticoid-induced bone loss
por: Shen, Geng-Yang, et al.
Publicado: (2019)

Meta-Analysis of Interleukin-2 Receptor Antagonists as the Treatment for Steroid-Refractory Acute Graft-Versus-Host Disease
por: Shen, Meng-Zhu, et al.
Publicado: (2021)

Duration of Suppression of Adrenal Steroids after Glucocorticoid Administration
por: Fuqua, John S., et al.
Publicado: (2010)

Sex steroids and glucocorticoid ratios in Iberian lynx hair
por: Azevedo, Alexandre, et al.
Publicado: (2020)

Mechanisms and Clinical Applications of Glucocorticoid Steroids in Muscular Dystrophy
por: Quattrocelli, Mattia, et al.
Publicado: (2021)

Contribution of local regeneration of glucocorticoids to tissue steroid pools
por: Khan, S, et al.
Publicado: (2022)

SP6616 as a Kv2.1 inhibitor efficiently ameliorates peripheral neuropathy in diabetic mice
por: Zhu, Xialin, et al.
Publicado: (2020)

Structural analysis of the evolution of steroid specificity in the mineralocorticoid and glucocorticoid receptors
por: Baker, Michael E, et al.
Publicado: (2007)

Inhibition of Spleen Tyrosine Kinase Restores Glucocorticoid Sensitivity to Improve Steroid-Resistant Asthma
por: Liu, Qian, et al.
Publicado: (2022)

SUN-739 Next Generation AR Antagonists Increase Systemic Active Glucocorticoid Exposure by Altering Glucocorticoid Metabolism
por: Alyamani, Mohammad, et al.
Publicado: (2020)

Antagonistic effects of gamma interferon and steroids on tissue antigenicity
Publicado: (1986)

Dragon blood resin ameliorates steroid-induced osteonecrosis of femoral head through osteoclastic pathways
por: Liu, Yuhao, et al.
Publicado: (2023)

Adipocyte glucocorticoid receptor is important in lipolysis and insulin resistance due to exogenous steroids, but not insulin resistance caused by high fat feeding
por: Shen, Yachen, et al.
Publicado: (2017)

Insights on Glucocorticoid Receptor Activity Modulation through the Binding of Rigid Steroids
por: Presman, Diego M., et al.
Publicado: (2010)

Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism
por: Arlt, Wiebke, et al.
Publicado: (2017)

Technetium-99 Conjugated with Methylene Diphosphonate Ameliorates Glucocorticoid Induced Osteoporosis by Inhibiting Osteoclastogenesis
por: Shi, Lianjie, et al.
Publicado: (2018)

Bone-targeting delivery of platelet lysate exosomes ameliorates glucocorticoid-induced osteoporosis by enhancing bone-vessel coupling
por: Zheng, Gang, et al.
Publicado: (2022)

Flow cytometry analysis of glucocorticoid receptor expression and binding in steroid-sensitive and steroid-resistant patients with systemic lupus erythematosus
por: Du, Juan, et al.
Publicado: (2009)

Targeting the TR4 nuclear receptor with antagonist bexarotene can suppress the proopiomelanocortin signalling in AtT‐20 cells
por: Xia, Liqun, et al.
Publicado: (2021)

Niacin Ameliorates Lipid Disturbances due to Glucocorticoid Administration in Rats
por: Safaei, Niloofar, et al.
Publicado: (2012)

Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma
Publicado: (1995)

Impairment of neutrophilic glucocorticoid receptor function in patients treated with steroids for septic shock
por: Bergquist, Maria, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_ns9un370haspk73i7mnoajsoe8