Ca(V)2.1 channel mutations causing familial hemiplegic migraine type 1 increase the susceptibility for cortical spreading depolarizations and seizures and worsen outcome after experimental traumatic brain injury

Patients suffering from familial hemiplegic migraine type 1 (FHM1) may have a disproportionally severe outcome after head trauma, but the underlying mechanisms are unclear. Hence, we subjected knock-in mice carrying the severer S218L or milder R192Q FHM1 gain-of-function missense mutation in the CAC...

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Detalles Bibliográficos
Autores principales: Terpolilli, Nicole A, Dolp, Reinhard, Waehner, Kai, Schwarzmaier, Susanne M, Rumbler, Elisabeth, Todorov, Boyan, Ferrari, Michel D, van den Maagdenberg, Arn MJM, Plesnila, Nikolaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920504/
https://www.ncbi.nlm.nih.gov/pubmed/35238776
http://dx.doi.org/10.7554/eLife.74923

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