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Effect of Probiotics on Respiratory Tract Allergic Disease and Gut Microbiota
Allergy is a hypersensitivity reaction triggered by specific cell or antibody-mediated immune mechanisms. Allergies have increased in industrialized countries in recent decades. The rise in allergic respiratory diseases such as allergic rhinitis (AR) and allergic asthma (AA) is a potential threat to...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920559/ https://www.ncbi.nlm.nih.gov/pubmed/35295917 http://dx.doi.org/10.3389/fnut.2022.821900 |
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author | Huang, Jinli Zhang, Juan Wang, Xingzhi Jin, Zenghui Zhang, Panpan Su, Hui Sun, Xin |
author_facet | Huang, Jinli Zhang, Juan Wang, Xingzhi Jin, Zenghui Zhang, Panpan Su, Hui Sun, Xin |
author_sort | Huang, Jinli |
collection | PubMed |
description | Allergy is a hypersensitivity reaction triggered by specific cell or antibody-mediated immune mechanisms. Allergies have increased in industrialized countries in recent decades. The rise in allergic respiratory diseases such as allergic rhinitis (AR) and allergic asthma (AA) is a potential threat to public health. Searches were conducted using PubMed, Google Scholar and Medline using the following key terms: allergic rhinitis OR asthma AND probiotics, allergic airway inflammation AND immune disorders, probiotics OR gut microbiota AND allergic disease, probiotics AND inflammatory. Studies from all years were included, specifically those published within the last 10 years. Some review articles and their reference lists were searched to identify related articles. The role of microbiota in respiratory allergic diseases has attracted more and more attention. Pieces of evidence suggested that the development of allergic diseases causes a possible imbalance in the composition of the gut microbiota. Compared to colonized mice, germ-free mice exhibit exaggerated allergic airway responses, suggesting that microbial host interactions play an important role in the development of allergic diseases. Probiotics modulate both the innate and adaptive inflammatory immune responses, often used as dietary supplements to provide health benefits in gastrointestinal disorders. Probiotics may serve as immunomodulators and activators of host defense pathways. Besides, oral probiotics can modulate the immune response in the respiratory system. Recently, studies in humans and animals have demonstrated the role of probiotic in RA and AA. To understand the characterization, microbiota, and the potential role of probiotics intervention of AA/AR, this review provides an overview of clinical features of AA and AR, probiotics for the prevention and treatment of AR, AA, changes in gut microbiota, and their mechanisms of action. |
format | Online Article Text |
id | pubmed-8920559 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89205592022-03-15 Effect of Probiotics on Respiratory Tract Allergic Disease and Gut Microbiota Huang, Jinli Zhang, Juan Wang, Xingzhi Jin, Zenghui Zhang, Panpan Su, Hui Sun, Xin Front Nutr Nutrition Allergy is a hypersensitivity reaction triggered by specific cell or antibody-mediated immune mechanisms. Allergies have increased in industrialized countries in recent decades. The rise in allergic respiratory diseases such as allergic rhinitis (AR) and allergic asthma (AA) is a potential threat to public health. Searches were conducted using PubMed, Google Scholar and Medline using the following key terms: allergic rhinitis OR asthma AND probiotics, allergic airway inflammation AND immune disorders, probiotics OR gut microbiota AND allergic disease, probiotics AND inflammatory. Studies from all years were included, specifically those published within the last 10 years. Some review articles and their reference lists were searched to identify related articles. The role of microbiota in respiratory allergic diseases has attracted more and more attention. Pieces of evidence suggested that the development of allergic diseases causes a possible imbalance in the composition of the gut microbiota. Compared to colonized mice, germ-free mice exhibit exaggerated allergic airway responses, suggesting that microbial host interactions play an important role in the development of allergic diseases. Probiotics modulate both the innate and adaptive inflammatory immune responses, often used as dietary supplements to provide health benefits in gastrointestinal disorders. Probiotics may serve as immunomodulators and activators of host defense pathways. Besides, oral probiotics can modulate the immune response in the respiratory system. Recently, studies in humans and animals have demonstrated the role of probiotic in RA and AA. To understand the characterization, microbiota, and the potential role of probiotics intervention of AA/AR, this review provides an overview of clinical features of AA and AR, probiotics for the prevention and treatment of AR, AA, changes in gut microbiota, and their mechanisms of action. Frontiers Media S.A. 2022-02-22 /pmc/articles/PMC8920559/ /pubmed/35295917 http://dx.doi.org/10.3389/fnut.2022.821900 Text en Copyright © 2022 Huang, Zhang, Wang, Jin, Zhang, Su and Sun. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Huang, Jinli Zhang, Juan Wang, Xingzhi Jin, Zenghui Zhang, Panpan Su, Hui Sun, Xin Effect of Probiotics on Respiratory Tract Allergic Disease and Gut Microbiota |
title | Effect of Probiotics on Respiratory Tract Allergic Disease and Gut Microbiota |
title_full | Effect of Probiotics on Respiratory Tract Allergic Disease and Gut Microbiota |
title_fullStr | Effect of Probiotics on Respiratory Tract Allergic Disease and Gut Microbiota |
title_full_unstemmed | Effect of Probiotics on Respiratory Tract Allergic Disease and Gut Microbiota |
title_short | Effect of Probiotics on Respiratory Tract Allergic Disease and Gut Microbiota |
title_sort | effect of probiotics on respiratory tract allergic disease and gut microbiota |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920559/ https://www.ncbi.nlm.nih.gov/pubmed/35295917 http://dx.doi.org/10.3389/fnut.2022.821900 |
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