Monoblastic leukemia (M5a) with chronic basophilic leukemia in a cat

A cat was presented with depression and anorexia. The complete blood cell count (CBC) revealed non-regenerative anemia (PCV, 8.5%), marked thrombocytopenia (2,400/µl), and leukocytosis (32,090/µl). In the peripheral blood, proliferation of blast cells (85%; 27,276/µl) and basophils (7.7%; 2,460/µl)...

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Detalles Bibliográficos
Autores principales: SHIMODA, Tetsuya, TANABE, Mika, SHOJI, Yuuki, KANDA, Takuya, KISHIDA, Kouhei, KISHIDA, Ai, HASHIMOTO, Atsushi, OTSUKA, Mako, MIYAMOTO, Akina, KAWAKITA, Tomoko, OSHITA, Wataru, HIRAO, Reijiro, SUWA, Akihisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2021
Materias:
Clinical Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920722/
https://www.ncbi.nlm.nih.gov/pubmed/34911870
http://dx.doi.org/10.1292/jvms.21-0383
Descripción
Sumario:A cat was presented with depression and anorexia. The complete blood cell count (CBC) revealed non-regenerative anemia (PCV, 8.5%), marked thrombocytopenia (2,400/µl), and leukocytosis (32,090/µl). In the peripheral blood, proliferation of blast cells (85%; 27,276/µl) and basophils (7.7%; 2,460/µl) was observed. Bone marrow aspirate showed hyperplasia with 8.8% blasts and 90.2% basophils of all nucleated cells. The blast cells were negative for myeloperoxidase staining and positive for alpha-naphthol butyrate esterase staining, indicating the agranular blasts are monoblasts. Thus, acute monoblastic leukemia (M5a) with chronic basophilic leukemia was diagnosed. Basophils accounted for more than 40% of the bone marrow, and we diagnosed secondary basophilic leukemia. Secondary basophilic leukemia should be included in the differential list when abnormal basophil increases are observed in feline bone marrow.

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