Engineered T cells and their therapeutic applications in autoimmune diseases

Chimeric antigen receptor T cells (CAR-T cells) are engineered recombinant T cells, which were initially used to treat hematopoietic malignancies and are now widely used in the treatment of various diseases. Considering their intrinsic targeting efficiency, CAR-T cells show considerable potential in...

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Detalles Bibliográficos
Autores principales: Bao, Lei, Bo, Xiao-Chen, Cao, Huai-Wen, Qian, Chen, Wang, Zeng, Li, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Science Press 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920845/
https://www.ncbi.nlm.nih.gov/pubmed/35008131
http://dx.doi.org/10.24272/j.issn.2095-8137.2021.363
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author Bao, Lei
Bo, Xiao-Chen
Cao, Huai-Wen
Qian, Chen
Wang, Zeng
Li, Bin
author_facet Bao, Lei
Bo, Xiao-Chen
Cao, Huai-Wen
Qian, Chen
Wang, Zeng
Li, Bin
author_sort Bao, Lei
collection PubMed
description Chimeric antigen receptor T cells (CAR-T cells) are engineered recombinant T cells, which were initially used to treat hematopoietic malignancies and are now widely used in the treatment of various diseases. Considering their intrinsic targeting efficiency, CAR-T cells show considerable potential in the treatment of autoimmune diseases. Furthermore, regulatory T cells (Treg), a subset of CD4 T cells exhibiting immunosuppressive functions, have attracted increasing attention regarding CAR-Treg cell production. In this review, we report on recent developments in preclinical and clinical studies on CAR-T cells in autoimmune diseases and provide an outlook on opportunities and challenges of CAR-T application in such diseases.
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spelling pubmed-89208452022-03-18 Engineered T cells and their therapeutic applications in autoimmune diseases Bao, Lei Bo, Xiao-Chen Cao, Huai-Wen Qian, Chen Wang, Zeng Li, Bin Zool Res Review Chimeric antigen receptor T cells (CAR-T cells) are engineered recombinant T cells, which were initially used to treat hematopoietic malignancies and are now widely used in the treatment of various diseases. Considering their intrinsic targeting efficiency, CAR-T cells show considerable potential in the treatment of autoimmune diseases. Furthermore, regulatory T cells (Treg), a subset of CD4 T cells exhibiting immunosuppressive functions, have attracted increasing attention regarding CAR-Treg cell production. In this review, we report on recent developments in preclinical and clinical studies on CAR-T cells in autoimmune diseases and provide an outlook on opportunities and challenges of CAR-T application in such diseases. Science Press 2022-03-18 /pmc/articles/PMC8920845/ /pubmed/35008131 http://dx.doi.org/10.24272/j.issn.2095-8137.2021.363 Text en Editorial Office of Zoological Research, Kunming Institute of Zoology, Chinese Academy of Sciences https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Bao, Lei
Bo, Xiao-Chen
Cao, Huai-Wen
Qian, Chen
Wang, Zeng
Li, Bin
Engineered T cells and their therapeutic applications in autoimmune diseases
title Engineered T cells and their therapeutic applications in autoimmune diseases
title_full Engineered T cells and their therapeutic applications in autoimmune diseases
title_fullStr Engineered T cells and their therapeutic applications in autoimmune diseases
title_full_unstemmed Engineered T cells and their therapeutic applications in autoimmune diseases
title_short Engineered T cells and their therapeutic applications in autoimmune diseases
title_sort engineered t cells and their therapeutic applications in autoimmune diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920845/
https://www.ncbi.nlm.nih.gov/pubmed/35008131
http://dx.doi.org/10.24272/j.issn.2095-8137.2021.363
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