Cargando…

Epidemiological and clinical characteristics of infections with seasonal human coronavirus and respiratory syncytial virus in hospitalized children immediately before the coronavirus disease 2019 pandemic

INTRODUCTION: Seasonal human coronavirus (HCoV)-229E, -NL63, -OC43, and -HKU1 are seasonal coronaviruses that cause colds in humans. However, the clinical characteristics of pediatric inpatients infected with HCoVs are unclear. This study aimed to compare and clarify the epidemiological and clinical...

Descripción completa

Detalles Bibliográficos
Autores principales: Kume, Yohei, Hashimoto, Koichi, Shirato, Kazuya, Norito, Sakurako, Suwa, Reiko, Chishiki, Mina, Ono, Takashi, Mashiyama, Fumi, Mochizuki, Izumi, Sato, Masatoki, Ishibashi, Naohisa, Suzuki, Shigeo, Sakuma, Hiroko, Takahashi, Hitoshi, Takeda, Makoto, Hosoya, Mitsuaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920880/
https://www.ncbi.nlm.nih.gov/pubmed/35307263
http://dx.doi.org/10.1016/j.jiac.2022.03.001
_version_ 1784669219642671104
author Kume, Yohei
Hashimoto, Koichi
Shirato, Kazuya
Norito, Sakurako
Suwa, Reiko
Chishiki, Mina
Ono, Takashi
Mashiyama, Fumi
Mochizuki, Izumi
Sato, Masatoki
Ishibashi, Naohisa
Suzuki, Shigeo
Sakuma, Hiroko
Takahashi, Hitoshi
Takeda, Makoto
Hosoya, Mitsuaki
author_facet Kume, Yohei
Hashimoto, Koichi
Shirato, Kazuya
Norito, Sakurako
Suwa, Reiko
Chishiki, Mina
Ono, Takashi
Mashiyama, Fumi
Mochizuki, Izumi
Sato, Masatoki
Ishibashi, Naohisa
Suzuki, Shigeo
Sakuma, Hiroko
Takahashi, Hitoshi
Takeda, Makoto
Hosoya, Mitsuaki
author_sort Kume, Yohei
collection PubMed
description INTRODUCTION: Seasonal human coronavirus (HCoV)-229E, -NL63, -OC43, and -HKU1 are seasonal coronaviruses that cause colds in humans. However, the clinical characteristics of pediatric inpatients infected with HCoVs are unclear. This study aimed to compare and clarify the epidemiological and clinical features of HCoVs and respiratory syncytial virus (RSV), which commonly causes severe respiratory infections in children. METHODS: Nasopharyngeal swabs were collected from all pediatric inpatients with respiratory symptoms at two secondary medical institutions in Fukushima, Japan. Eighteen respiratory viruses, including RSV and four HCoVs, were detected via reverse transcription-polymerase chain reaction. RESULTS: Of the 1757 specimens tested, viruses were detected in 1272 specimens (72.4%), with 789 single (44.9%) and 483 multiple virus detections (27.5%). RSV was detected in 639 patients (36.4%) with no difference in clinical characteristics between RSV-A and RSV-B. HCoV was detected in 84 patients (4.7%): OC43, NL63, HKU1, and 229E in 25 (1.4%), 26 (1.5%), 23 (1.3%), and 16 patients (0.9%), respectively. Patients with HCoV monoinfection (n = 35) had a significantly shorter period from onset to hospitalization (median [interquartile range] days, 2 [1–4.5] vs. 4 [2–5]), significantly shorter hospitalization stays (4 [3–5] vs. 5 [4–6]), and more cases of upper respiratory infections (37.1% vs. 3.9%) and croup (17.1% vs. 0.3%) but less cases of lower respiratory infection (54.3% vs. 94.8%) than patients with RSV monoinfection (n = 362). CONCLUSION: Seasonal HCoV-infected patients account for approximately 5% of children hospitalized for respiratory tract infections and have fewer lower respiratory infections and shorter hospital stays than RSV-infected patients.
format Online
Article
Text
id pubmed-8920880
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd.
record_format MEDLINE/PubMed
spelling pubmed-89208802022-03-15 Epidemiological and clinical characteristics of infections with seasonal human coronavirus and respiratory syncytial virus in hospitalized children immediately before the coronavirus disease 2019 pandemic Kume, Yohei Hashimoto, Koichi Shirato, Kazuya Norito, Sakurako Suwa, Reiko Chishiki, Mina Ono, Takashi Mashiyama, Fumi Mochizuki, Izumi Sato, Masatoki Ishibashi, Naohisa Suzuki, Shigeo Sakuma, Hiroko Takahashi, Hitoshi Takeda, Makoto Hosoya, Mitsuaki J Infect Chemother Original Article INTRODUCTION: Seasonal human coronavirus (HCoV)-229E, -NL63, -OC43, and -HKU1 are seasonal coronaviruses that cause colds in humans. However, the clinical characteristics of pediatric inpatients infected with HCoVs are unclear. This study aimed to compare and clarify the epidemiological and clinical features of HCoVs and respiratory syncytial virus (RSV), which commonly causes severe respiratory infections in children. METHODS: Nasopharyngeal swabs were collected from all pediatric inpatients with respiratory symptoms at two secondary medical institutions in Fukushima, Japan. Eighteen respiratory viruses, including RSV and four HCoVs, were detected via reverse transcription-polymerase chain reaction. RESULTS: Of the 1757 specimens tested, viruses were detected in 1272 specimens (72.4%), with 789 single (44.9%) and 483 multiple virus detections (27.5%). RSV was detected in 639 patients (36.4%) with no difference in clinical characteristics between RSV-A and RSV-B. HCoV was detected in 84 patients (4.7%): OC43, NL63, HKU1, and 229E in 25 (1.4%), 26 (1.5%), 23 (1.3%), and 16 patients (0.9%), respectively. Patients with HCoV monoinfection (n = 35) had a significantly shorter period from onset to hospitalization (median [interquartile range] days, 2 [1–4.5] vs. 4 [2–5]), significantly shorter hospitalization stays (4 [3–5] vs. 5 [4–6]), and more cases of upper respiratory infections (37.1% vs. 3.9%) and croup (17.1% vs. 0.3%) but less cases of lower respiratory infection (54.3% vs. 94.8%) than patients with RSV monoinfection (n = 362). CONCLUSION: Seasonal HCoV-infected patients account for approximately 5% of children hospitalized for respiratory tract infections and have fewer lower respiratory infections and shorter hospital stays than RSV-infected patients. Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. 2022-07 2022-03-15 /pmc/articles/PMC8920880/ /pubmed/35307263 http://dx.doi.org/10.1016/j.jiac.2022.03.001 Text en © 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Article
Kume, Yohei
Hashimoto, Koichi
Shirato, Kazuya
Norito, Sakurako
Suwa, Reiko
Chishiki, Mina
Ono, Takashi
Mashiyama, Fumi
Mochizuki, Izumi
Sato, Masatoki
Ishibashi, Naohisa
Suzuki, Shigeo
Sakuma, Hiroko
Takahashi, Hitoshi
Takeda, Makoto
Hosoya, Mitsuaki
Epidemiological and clinical characteristics of infections with seasonal human coronavirus and respiratory syncytial virus in hospitalized children immediately before the coronavirus disease 2019 pandemic
title Epidemiological and clinical characteristics of infections with seasonal human coronavirus and respiratory syncytial virus in hospitalized children immediately before the coronavirus disease 2019 pandemic
title_full Epidemiological and clinical characteristics of infections with seasonal human coronavirus and respiratory syncytial virus in hospitalized children immediately before the coronavirus disease 2019 pandemic
title_fullStr Epidemiological and clinical characteristics of infections with seasonal human coronavirus and respiratory syncytial virus in hospitalized children immediately before the coronavirus disease 2019 pandemic
title_full_unstemmed Epidemiological and clinical characteristics of infections with seasonal human coronavirus and respiratory syncytial virus in hospitalized children immediately before the coronavirus disease 2019 pandemic
title_short Epidemiological and clinical characteristics of infections with seasonal human coronavirus and respiratory syncytial virus in hospitalized children immediately before the coronavirus disease 2019 pandemic
title_sort epidemiological and clinical characteristics of infections with seasonal human coronavirus and respiratory syncytial virus in hospitalized children immediately before the coronavirus disease 2019 pandemic
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920880/
https://www.ncbi.nlm.nih.gov/pubmed/35307263
http://dx.doi.org/10.1016/j.jiac.2022.03.001
work_keys_str_mv AT kumeyohei epidemiologicalandclinicalcharacteristicsofinfectionswithseasonalhumancoronavirusandrespiratorysyncytialvirusinhospitalizedchildrenimmediatelybeforethecoronavirusdisease2019pandemic
AT hashimotokoichi epidemiologicalandclinicalcharacteristicsofinfectionswithseasonalhumancoronavirusandrespiratorysyncytialvirusinhospitalizedchildrenimmediatelybeforethecoronavirusdisease2019pandemic
AT shiratokazuya epidemiologicalandclinicalcharacteristicsofinfectionswithseasonalhumancoronavirusandrespiratorysyncytialvirusinhospitalizedchildrenimmediatelybeforethecoronavirusdisease2019pandemic
AT noritosakurako epidemiologicalandclinicalcharacteristicsofinfectionswithseasonalhumancoronavirusandrespiratorysyncytialvirusinhospitalizedchildrenimmediatelybeforethecoronavirusdisease2019pandemic
AT suwareiko epidemiologicalandclinicalcharacteristicsofinfectionswithseasonalhumancoronavirusandrespiratorysyncytialvirusinhospitalizedchildrenimmediatelybeforethecoronavirusdisease2019pandemic
AT chishikimina epidemiologicalandclinicalcharacteristicsofinfectionswithseasonalhumancoronavirusandrespiratorysyncytialvirusinhospitalizedchildrenimmediatelybeforethecoronavirusdisease2019pandemic
AT onotakashi epidemiologicalandclinicalcharacteristicsofinfectionswithseasonalhumancoronavirusandrespiratorysyncytialvirusinhospitalizedchildrenimmediatelybeforethecoronavirusdisease2019pandemic
AT mashiyamafumi epidemiologicalandclinicalcharacteristicsofinfectionswithseasonalhumancoronavirusandrespiratorysyncytialvirusinhospitalizedchildrenimmediatelybeforethecoronavirusdisease2019pandemic
AT mochizukiizumi epidemiologicalandclinicalcharacteristicsofinfectionswithseasonalhumancoronavirusandrespiratorysyncytialvirusinhospitalizedchildrenimmediatelybeforethecoronavirusdisease2019pandemic
AT satomasatoki epidemiologicalandclinicalcharacteristicsofinfectionswithseasonalhumancoronavirusandrespiratorysyncytialvirusinhospitalizedchildrenimmediatelybeforethecoronavirusdisease2019pandemic
AT ishibashinaohisa epidemiologicalandclinicalcharacteristicsofinfectionswithseasonalhumancoronavirusandrespiratorysyncytialvirusinhospitalizedchildrenimmediatelybeforethecoronavirusdisease2019pandemic
AT suzukishigeo epidemiologicalandclinicalcharacteristicsofinfectionswithseasonalhumancoronavirusandrespiratorysyncytialvirusinhospitalizedchildrenimmediatelybeforethecoronavirusdisease2019pandemic
AT sakumahiroko epidemiologicalandclinicalcharacteristicsofinfectionswithseasonalhumancoronavirusandrespiratorysyncytialvirusinhospitalizedchildrenimmediatelybeforethecoronavirusdisease2019pandemic
AT takahashihitoshi epidemiologicalandclinicalcharacteristicsofinfectionswithseasonalhumancoronavirusandrespiratorysyncytialvirusinhospitalizedchildrenimmediatelybeforethecoronavirusdisease2019pandemic
AT takedamakoto epidemiologicalandclinicalcharacteristicsofinfectionswithseasonalhumancoronavirusandrespiratorysyncytialvirusinhospitalizedchildrenimmediatelybeforethecoronavirusdisease2019pandemic
AT hosoyamitsuaki epidemiologicalandclinicalcharacteristicsofinfectionswithseasonalhumancoronavirusandrespiratorysyncytialvirusinhospitalizedchildrenimmediatelybeforethecoronavirusdisease2019pandemic