DNA replication fork speed underlies cell fate changes and promotes reprogramming

Totipotency emerges in early embryogenesis, but its molecular underpinnings remain poorly characterized. In the present study, we employed DNA fiber analysis to investigate how pluripotent stem cells are reprogrammed into totipotent-like 2-cell-like cells (2CLCs). We show that totipotent cells of th...

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Detalles Bibliográficos
Autores principales: Nakatani, Tsunetoshi, Lin, Jiangwei, Ji, Fei, Ettinger, Andreas, Pontabry, Julien, Tokoro, Mikiko, Altamirano-Pacheco, Luis, Fiorentino, Jonathan, Mahammadov, Elmir, Hatano, Yu, Van Rechem, Capucine, Chakraborty, Damayanti, Ruiz-Morales, Elias R., Arguello Pascualli, Paola Y., Scialdone, Antonio, Yamagata, Kazuo, Whetstine, Johnathan R., Sadreyev, Ruslan I., Torres-Padilla, Maria-Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920892/
https://www.ncbi.nlm.nih.gov/pubmed/35256805
http://dx.doi.org/10.1038/s41588-022-01023-0

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