A hydrophilic microenvironment in the substrate-translocating groove of the YidC membrane insertase is essential for enzyme function

The YidC family of proteins are membrane insertases that catalyze the translocation of the periplasmic domain of membrane proteins via a hydrophilic groove located within the inner leaflet of the membrane. All homologs have a strictly conserved, positively charged residue in the center of this groov...

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Detalles Bibliográficos
Autores principales: Chen, Yuanyuan, Sotomayor, Marcos, Capponi, Sara, Hariharan, Balasubramani, Sahu, Indra D., Haase, Maximilian, Lorigan, Gary A., Kuhn, Andreas, White, Stephen H., Dalbey, Ross E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920935/
https://www.ncbi.nlm.nih.gov/pubmed/35148995
http://dx.doi.org/10.1016/j.jbc.2022.101690

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