Cargando…

ALKBH5-Mediated m(6)A Modification of A20 Regulates Microglia Polarization in Diabetic Retinopathy

BACKGROUND: To investigate the role of microglia polarization in the pathogenesis of diabetic retinopathy, and study the mechanism of ALKBH5-mediated m(6)A modification of A20 of retinal microglia polarization. METHODS: Diabetics rats were constructed and the M1/M2 polarization of retinal microglia...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Tingting, Zhu, Wenhui, Wang, Congyao, Dong, Xia, Yu, Fenfen, Su, Yihua, Huang, Jingwen, Huo, Lijun, Wan, Pengxia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920977/ https://www.ncbi.nlm.nih.gov/pubmed/35300330 http://dx.doi.org/10.3389/fimmu.2022.813979

Ejemplares similares

Comprehensive analysis of ferritinophagy-related genes and immune infiltration landscape in diabetic retinopathy
por: Yu, Fenfen, et al.
Publicado: (2023)

Microglia and Inflammatory Responses in Diabetic Retinopathy
por: Kinuthia, Urbanus Muthai, et al.
Publicado: (2020)

Macrophage/microglia polarization for the treatment of diabetic retinopathy
por: Yao, Yujia, et al.
Publicado: (2023)

In Search for Reliable Markers of Glioma-Induced Polarization of Microglia
por: Walentynowicz, Kacper A., et al.
Publicado: (2018)

Advances in the research of the role of macrophage/microglia polarization-mediated inflammatory response in spinal cord injury
por: Fu, Sheng-Ping, et al.
Publicado: (2022)

Visual Impairments Are Associated With Retinal Microvascular Density in Patients With Parkinson’s Disease
por: Zhou, Min, et al.
Publicado: (2021)

Fine-tuning of microglia polarization prevents diabetes-associated cerebral atherosclerosis
por: Zhu, Xuan, et al.
Publicado: (2022)

SIRT1 Promotes M2 Microglia Polarization via Reducing ROS-Mediated NLRP3 Inflammasome Signaling After Subarachnoid Hemorrhage
por: Xia, Da-Yong, et al.
Publicado: (2021)

Adiponectin Ameliorates GMH-Induced Brain Injury by Regulating Microglia M1/M2 Polarization Via AdipoR1/APPL1/AMPK/PPARγ Signaling Pathway in Neonatal Rats
por: Xu, Ningbo, et al.
Publicado: (2022)

ALKBH5 promotes PD-L1-mediated immune escape through m6A modification of ZDHHC3 in glioma
por: Tang, Wenhui, et al.
Publicado: (2022)

SIRT1 activation by 2,3,5,6-tetramethylpyrazine alleviates neuroinflammation via inhibiting M1 microglia polarization
por: Chen, Yu, et al.
Publicado: (2023)

ALKBH1 is an RNA dioxygenase responsible for cytoplasmic and mitochondrial tRNA modifications
por: Kawarada, Layla, et al.
Publicado: (2017)

Inhibition of Notch1 Signaling Alleviates Endotoxin-Induced Inflammation Through Modulating Retinal Microglia Polarization
por: Cheng, Zhixing, et al.
Publicado: (2019)

Individual in vivo Profiles of Microglia Polarization After Stroke, Represented by the Genes iNOS and Ym1
por: Collmann, Franziska M., et al.
Publicado: (2019)

Are “Resting” Microglia More “M2”?
por: Cherry, Jonathan D., et al.
Publicado: (2014)

Pan-Cancer Analysis Shows That ALKBH5 Is a Potential Prognostic and Immunotherapeutic Biomarker for Multiple Cancer Types Including Gliomas
por: Wei, Cheng, et al.
Publicado: (2022)

The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review
por: Zeng, Jinsong, et al.
Publicado: (2023)

Integrated multi-omics reveals the activated retinal microglia with intracellular metabolic reprogramming contributes to inflammation in STZ-induced early diabetic retinopathy
por: Lv, Kangjia, et al.
Publicado: (2022)

Corrigendum: Pan-Cancer Analysis Shows That ALKBH5 Is a Potential Prognostic and Immunotherapeutic Biomarker for Multiple Cancer Types Including Gliomas
por: Wei, Cheng, et al.
Publicado: (2022)

Ferulic acid alleviates retinal neovascularization by modulating microglia/macrophage polarization through the ROS/NF-κB axis
por: Sun, Xiaowei, et al.
Publicado: (2022)

Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification
por: Hu, Yiyang, et al.
Publicado: (2022)

The Role of Microglia in Diabetic Retinopathy
por: Grigsby, Jeffery G., et al.
Publicado: (2014)

Abnormal Decrease of Macrophage ALKBH5 Expression Causes Abnormal Polarization and Inhibits Osteoblast Differentiation
por: Weng, Junquan, et al.
Publicado: (2023)

Downregulated ALKBH5 contributes to myocardial ischemia/reperfusion injury by increasing m(6)A modification of Trio mRNA
por: Li, Jiaxin, et al.
Publicado: (2022)

Protozoan ALKBH8 Oxygenases Display both DNA Repair and tRNA Modification Activities
por: Zdżalik, Daria, et al.
Publicado: (2014)

Advances in the role of STAT3 in macrophage polarization
por: Xia, Tingting, et al.
Publicado: (2023)

Microglia in Retinal Degeneration
por: Rashid, Khalid, et al.
Publicado: (2019)

Editorial: Microglia in neuroinflammation
por: Ayata, Pinar, et al.
Publicado: (2023)

Association of Clinical Phenotypes in Haploinsufficiency A20 (HA20) With Disrupted Domains of A20
por: Chen, Yu, et al.
Publicado: (2020)

LncRNA ALKBH3‐AS1 enhances ALKBH3 mRNA stability to promote hepatocellular carcinoma cell proliferation and invasion
por: Lu, Qiliang, et al.
Publicado: (2022)

Proteasome-dependent senescent tumor cells mediate immunosuppression through CCL20 secretion and M2 polarization in pancreatic ductal adenocarcinoma
por: Wu, Mengwei, et al.
Publicado: (2023)

Roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics
por: Fang, Shaoyi, et al.
Publicado: (2023)

Mechanism and Regulation of Microglia Polarization in Intracerebral Hemorrhage
por: Guo, Yuting, et al.
Publicado: (2022)

Nutritional and Nanotechnological Modulators of Microglia
por: Maysinger, Dusica, et al.
Publicado: (2016)

Microglia: Immune Regulators of Neurodevelopment
por: Cowan, Maureen, et al.
Publicado: (2018)

Microbiota and Microglia Interactions in ASD
por: Davoli-Ferreira, Marcela, et al.
Publicado: (2021)

Post-translational modification of RNA m(6)A demethylase ALKBH5 regulates ROS-induced DNA damage response
por: Yu, Fang, et al.
Publicado: (2021)

Modulators of microglia activation and polarization in ischemic stroke
por: Jiang, Cheng-Ting, et al.
Publicado: (2020)

Associations of genetically predicted circulating levels of cytokines with telomere length: a Mendelian randomization study
por: Pan, Renbing, et al.
Publicado: (2023)

ALKBH3-dependent m(1)A demethylation of Aurora A mRNA inhibits ciliogenesis
por: Kuang, Wenjun, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_er4pn9cp2bkmnv9ra1quad72qq