An ex vivo perfused ventilated murine lung model suggests lack of acute pulmonary toxicity of the potential novel anticancer agent (−)-englerin A

(−)-Englerin A (EA), a potential novel anti-cancer drug, is a potent selective activator of classical transient receptor potential 4 and 5 (TRPC4, TRPC5) channels. As TRPC4 channels are expressed and functional in the lung endothelium, possible side effects such as lung edema formation may arise dur...

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Detalles Bibliográficos
Autores principales: Schremmer, Christian, Steinritz, Dirk, Gudermann, Thomas, Beech, David J., Dietrich, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Organ Toxicity and Mechanisms
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921049/
https://www.ncbi.nlm.nih.gov/pubmed/35165752
http://dx.doi.org/10.1007/s00204-022-03235-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921049/
https://www.ncbi.nlm.nih.gov/pubmed/35165752
http://dx.doi.org/10.1007/s00204-022-03235-z

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