Cargando…

Laparoscopic gastrectomy for stage II and III advanced gastric cancer: long‑term follow‑up data from a Western multicenter retrospective study

INTRODUCTION: There has been an increasing interest for the laparoscopic treatment of early gastric cancer, especially among Eastern surgeons. However, the oncological effectiveness of Laparoscopic Gastrectomy (LG) for Advanced Gastric Cancer (AGC) remains a subject of debate, especially in Western...

Descripción completa

Detalles Bibliográficos
Autores principales: Bracale, Umberto, Merola, Giovanni, Pignata, Giusto, Andreuccetti, Jacopo, Dolce, Pasquale, Boni, Luigi, Cassinotti, Elisa, Olmi, Stefano, Uccelli, Matteo, Gualtierotti, Monica, Ferrari, Giovanni, De Martini, Paolo, Bjelović, Miloš, Gunjić, Dragan, Silvestri, Vania, Pontecorvi, Emanuele, Peltrini, Roberto, Pirozzi, Felice, Cuccurullo, Diego, Sciuto, Antonio, Corcione, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921054/
https://www.ncbi.nlm.nih.gov/pubmed/33877411
http://dx.doi.org/10.1007/s00464-021-08505-y
_version_ 1784669253397381120
author Bracale, Umberto
Merola, Giovanni
Pignata, Giusto
Andreuccetti, Jacopo
Dolce, Pasquale
Boni, Luigi
Cassinotti, Elisa
Olmi, Stefano
Uccelli, Matteo
Gualtierotti, Monica
Ferrari, Giovanni
De Martini, Paolo
Bjelović, Miloš
Gunjić, Dragan
Silvestri, Vania
Pontecorvi, Emanuele
Peltrini, Roberto
Pirozzi, Felice
Cuccurullo, Diego
Sciuto, Antonio
Corcione, Francesco
author_facet Bracale, Umberto
Merola, Giovanni
Pignata, Giusto
Andreuccetti, Jacopo
Dolce, Pasquale
Boni, Luigi
Cassinotti, Elisa
Olmi, Stefano
Uccelli, Matteo
Gualtierotti, Monica
Ferrari, Giovanni
De Martini, Paolo
Bjelović, Miloš
Gunjić, Dragan
Silvestri, Vania
Pontecorvi, Emanuele
Peltrini, Roberto
Pirozzi, Felice
Cuccurullo, Diego
Sciuto, Antonio
Corcione, Francesco
author_sort Bracale, Umberto
collection PubMed
description INTRODUCTION: There has been an increasing interest for the laparoscopic treatment of early gastric cancer, especially among Eastern surgeons. However, the oncological effectiveness of Laparoscopic Gastrectomy (LG) for Advanced Gastric Cancer (AGC) remains a subject of debate, especially in Western countries where limited reports have been published. The aim of this paper is to retrospectively analyze short- and long-term results of LG for AGC in a real-life Western practice. MATERIALS AND METHODS: All consecutive cases of LG with D2 lymphadenectomy for AGC performed from January 2005 to December 2019 at seven different surgical departments were analyzed retrospectively. The primary outcome was diseases-free survival (DFS). Secondary outcomes were overall survival (OS), number of retrieved lymph nodes, postoperative morbidity and conversion rate. RESULTS: A total of 366 patients with stage II and III AGC underwent either total or subtotal LG. The mean number of harvested lymph nodes was 25 ± 14. The mean hospital stay was 13 ± 10 days and overall postoperative morbidity rate 27.32%, with severe complications (grade ≥ III) accounting for 9.29%. The median follow-up was 36 ± 16 months during which 90 deaths occurred, all due to disease progression. The DFS and OS probability was equal to 0.85 (95% CI 0.81–0.89) and 0.94 (95% CI 0.92–0.97) at 1 year, 0.62 (95% CI 0.55–0.69) and 0.63 (95% CI 0.56–0.71) at 5 years, respectively. CONCLUSION: Our study has led us to conclude that LG for AGC is feasible and safe in the general practice of Western institutions when performed by trained surgeons.
format Online
Article
Text
id pubmed-8921054
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-89210542022-03-17 Laparoscopic gastrectomy for stage II and III advanced gastric cancer: long‑term follow‑up data from a Western multicenter retrospective study Bracale, Umberto Merola, Giovanni Pignata, Giusto Andreuccetti, Jacopo Dolce, Pasquale Boni, Luigi Cassinotti, Elisa Olmi, Stefano Uccelli, Matteo Gualtierotti, Monica Ferrari, Giovanni De Martini, Paolo Bjelović, Miloš Gunjić, Dragan Silvestri, Vania Pontecorvi, Emanuele Peltrini, Roberto Pirozzi, Felice Cuccurullo, Diego Sciuto, Antonio Corcione, Francesco Surg Endosc Article INTRODUCTION: There has been an increasing interest for the laparoscopic treatment of early gastric cancer, especially among Eastern surgeons. However, the oncological effectiveness of Laparoscopic Gastrectomy (LG) for Advanced Gastric Cancer (AGC) remains a subject of debate, especially in Western countries where limited reports have been published. The aim of this paper is to retrospectively analyze short- and long-term results of LG for AGC in a real-life Western practice. MATERIALS AND METHODS: All consecutive cases of LG with D2 lymphadenectomy for AGC performed from January 2005 to December 2019 at seven different surgical departments were analyzed retrospectively. The primary outcome was diseases-free survival (DFS). Secondary outcomes were overall survival (OS), number of retrieved lymph nodes, postoperative morbidity and conversion rate. RESULTS: A total of 366 patients with stage II and III AGC underwent either total or subtotal LG. The mean number of harvested lymph nodes was 25 ± 14. The mean hospital stay was 13 ± 10 days and overall postoperative morbidity rate 27.32%, with severe complications (grade ≥ III) accounting for 9.29%. The median follow-up was 36 ± 16 months during which 90 deaths occurred, all due to disease progression. The DFS and OS probability was equal to 0.85 (95% CI 0.81–0.89) and 0.94 (95% CI 0.92–0.97) at 1 year, 0.62 (95% CI 0.55–0.69) and 0.63 (95% CI 0.56–0.71) at 5 years, respectively. CONCLUSION: Our study has led us to conclude that LG for AGC is feasible and safe in the general practice of Western institutions when performed by trained surgeons. Springer US 2021-04-20 2022 /pmc/articles/PMC8921054/ /pubmed/33877411 http://dx.doi.org/10.1007/s00464-021-08505-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Bracale, Umberto
Merola, Giovanni
Pignata, Giusto
Andreuccetti, Jacopo
Dolce, Pasquale
Boni, Luigi
Cassinotti, Elisa
Olmi, Stefano
Uccelli, Matteo
Gualtierotti, Monica
Ferrari, Giovanni
De Martini, Paolo
Bjelović, Miloš
Gunjić, Dragan
Silvestri, Vania
Pontecorvi, Emanuele
Peltrini, Roberto
Pirozzi, Felice
Cuccurullo, Diego
Sciuto, Antonio
Corcione, Francesco
Laparoscopic gastrectomy for stage II and III advanced gastric cancer: long‑term follow‑up data from a Western multicenter retrospective study
title Laparoscopic gastrectomy for stage II and III advanced gastric cancer: long‑term follow‑up data from a Western multicenter retrospective study
title_full Laparoscopic gastrectomy for stage II and III advanced gastric cancer: long‑term follow‑up data from a Western multicenter retrospective study
title_fullStr Laparoscopic gastrectomy for stage II and III advanced gastric cancer: long‑term follow‑up data from a Western multicenter retrospective study
title_full_unstemmed Laparoscopic gastrectomy for stage II and III advanced gastric cancer: long‑term follow‑up data from a Western multicenter retrospective study
title_short Laparoscopic gastrectomy for stage II and III advanced gastric cancer: long‑term follow‑up data from a Western multicenter retrospective study
title_sort laparoscopic gastrectomy for stage ii and iii advanced gastric cancer: long‑term follow‑up data from a western multicenter retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921054/
https://www.ncbi.nlm.nih.gov/pubmed/33877411
http://dx.doi.org/10.1007/s00464-021-08505-y
work_keys_str_mv AT bracaleumberto laparoscopicgastrectomyforstageiiandiiiadvancedgastriccancerlongtermfollowupdatafromawesternmulticenterretrospectivestudy
AT merolagiovanni laparoscopicgastrectomyforstageiiandiiiadvancedgastriccancerlongtermfollowupdatafromawesternmulticenterretrospectivestudy
AT pignatagiusto laparoscopicgastrectomyforstageiiandiiiadvancedgastriccancerlongtermfollowupdatafromawesternmulticenterretrospectivestudy
AT andreuccettijacopo laparoscopicgastrectomyforstageiiandiiiadvancedgastriccancerlongtermfollowupdatafromawesternmulticenterretrospectivestudy
AT dolcepasquale laparoscopicgastrectomyforstageiiandiiiadvancedgastriccancerlongtermfollowupdatafromawesternmulticenterretrospectivestudy
AT boniluigi laparoscopicgastrectomyforstageiiandiiiadvancedgastriccancerlongtermfollowupdatafromawesternmulticenterretrospectivestudy
AT cassinottielisa laparoscopicgastrectomyforstageiiandiiiadvancedgastriccancerlongtermfollowupdatafromawesternmulticenterretrospectivestudy
AT olmistefano laparoscopicgastrectomyforstageiiandiiiadvancedgastriccancerlongtermfollowupdatafromawesternmulticenterretrospectivestudy
AT uccellimatteo laparoscopicgastrectomyforstageiiandiiiadvancedgastriccancerlongtermfollowupdatafromawesternmulticenterretrospectivestudy
AT gualtierottimonica laparoscopicgastrectomyforstageiiandiiiadvancedgastriccancerlongtermfollowupdatafromawesternmulticenterretrospectivestudy
AT ferrarigiovanni laparoscopicgastrectomyforstageiiandiiiadvancedgastriccancerlongtermfollowupdatafromawesternmulticenterretrospectivestudy
AT demartinipaolo laparoscopicgastrectomyforstageiiandiiiadvancedgastriccancerlongtermfollowupdatafromawesternmulticenterretrospectivestudy
AT bjelovicmilos laparoscopicgastrectomyforstageiiandiiiadvancedgastriccancerlongtermfollowupdatafromawesternmulticenterretrospectivestudy
AT gunjicdragan laparoscopicgastrectomyforstageiiandiiiadvancedgastriccancerlongtermfollowupdatafromawesternmulticenterretrospectivestudy
AT silvestrivania laparoscopicgastrectomyforstageiiandiiiadvancedgastriccancerlongtermfollowupdatafromawesternmulticenterretrospectivestudy
AT pontecorviemanuele laparoscopicgastrectomyforstageiiandiiiadvancedgastriccancerlongtermfollowupdatafromawesternmulticenterretrospectivestudy
AT peltriniroberto laparoscopicgastrectomyforstageiiandiiiadvancedgastriccancerlongtermfollowupdatafromawesternmulticenterretrospectivestudy
AT pirozzifelice laparoscopicgastrectomyforstageiiandiiiadvancedgastriccancerlongtermfollowupdatafromawesternmulticenterretrospectivestudy
AT cuccurullodiego laparoscopicgastrectomyforstageiiandiiiadvancedgastriccancerlongtermfollowupdatafromawesternmulticenterretrospectivestudy
AT sciutoantonio laparoscopicgastrectomyforstageiiandiiiadvancedgastriccancerlongtermfollowupdatafromawesternmulticenterretrospectivestudy
AT corcionefrancesco laparoscopicgastrectomyforstageiiandiiiadvancedgastriccancerlongtermfollowupdatafromawesternmulticenterretrospectivestudy