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In vitro Dissolution Testing and Pharmacokinetic Studies of Silymarin Solid Dispersion After Oral Administration to Healthy Pigs

We evaluated the pharmacokinetics of silymarin solid dispersion in pigs to determine whether silybin bioavailability would be increased over that of a silymarin premix. In vitro dissolution testing was conducted using dissolution apparatus 1 (baskets) at 100 rpm at 37 ± 0.5°C in pH 1.2 HCl, pH 6.8 p...

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Detalles Bibliográficos
Autores principales:	Xu, Ying, Li, Jie, He, Bing, Feng, Tingsong, Liang, Lijie, Huang, Xianhui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Veterinary Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921073/ https://www.ncbi.nlm.nih.gov/pubmed/35300217 http://dx.doi.org/10.3389/fvets.2022.815198

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