Preclinical characterization of [(18)F]T-008, a novel PET imaging radioligand for cholesterol 24-hydroxylase

PURPOSE: Cholesterol 24-hydroxylase (CH24H) is a brain-specific enzyme that plays a major role in brain cholesterol homeostasis by converting cholesterol into 24S-hydroxycholesterol. The selective CH24H inhibitor soticlestat (TAK-935) is being pursued as a drug for treatment of seizures in developme...

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Detalles Bibliográficos
Autores principales: Koike, Tatsuki, Constantinescu, Cristian C., Ikeda, Shuhei, Nishi, Toshiya, Sunahara, Eiji, Miyamoto, Maki, Cole, Patricia, Barret, Olivier, Alagille, David, Papin, Caroline, Morley, Thomas, Fowles, Krista, Seibyl, John, Tamagnan, Gilles, Kuroita, Takanobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921165/
https://www.ncbi.nlm.nih.gov/pubmed/34651220
http://dx.doi.org/10.1007/s00259-021-05565-z

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