Lysosomal Ca(2+)-mediated TFEB activation modulates mitophagy and functional adaptation of pancreatic β-cells to metabolic stress

Although autophagy is critical for pancreatic β-cell function, the role and mechanism of mitophagy in β-cells are unclear. We studied the role of lysosomal Ca(2+) in TFEB activation by mitochondrial or metabolic stress and that of TFEB-mediated mitophagy in β-cell function. Mitochondrial or metaboli...

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Detalles Bibliográficos
Autores principales: Park, Kihyoun, Lim, Hyejin, Kim, Jinyoung, Hwang, Yeseong, Lee, Yu Seol, Bae, Soo Han, Kim, Hyeongseok, Kim, Hail, Kang, Shin-Wook, Kim, Joo Young, Lee, Myung-Shik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921223/
https://www.ncbi.nlm.nih.gov/pubmed/35288580
http://dx.doi.org/10.1038/s41467-022-28874-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921223/
https://www.ncbi.nlm.nih.gov/pubmed/35288580
http://dx.doi.org/10.1038/s41467-022-28874-9

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