GSDMD enhances cisplatin-induced apoptosis by promoting the phosphorylation of eIF2α and activating the ER-stress response

GSDMD is the key effector of pyroptosis, but its non-pyroptosis-related functions have seldom been reported. Here, we report that GSDMD is overexpressed in different types of tumours, including head and neck squamous-cell carcinoma, and it promotes the sensitivity of tumour cells to cisplatin. Unexp...

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Detalles Bibliográficos
Autores principales: Zhang, Qianyu, Huang, Zixian, Rui, Xi, Wang, Yan, Wang, Yongqiang, Zhou, Yuwei, Chen, Rui, Chen, Yongju, Wang, Yuepeng, Li, Shihao, Li, Haigang, Shen, Ximing, Liang, Yancan, Zhang, Yin, Huang, Zhiquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921229/
https://www.ncbi.nlm.nih.gov/pubmed/35289335
http://dx.doi.org/10.1038/s41420-022-00915-8

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