Modulation of myosin by cardiac myosin binding protein-C peptides improves cardiac contractility in ex-vivo experimental heart failure models

Cardiac myosin binding protein-C (cMyBP-C) is an important regulator of sarcomeric function. Reduced phosphorylation of cMyBP-C has been linked to compromised contractility in heart failure patients. Here, we used previously published cMyBP-C peptides 302A and 302S, surrogates of the regulatory phos...

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Detalles Bibliográficos
Autores principales: Hou, Luqia, Kumar, Mohit, Anand, Priti, Chen, Yinhong, El-Bizri, Nesrine, Pickens, Chad J., Seganish, W. Michael, Sadayappan, Sakthivel, Swaminath, Gayathri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921245/
https://www.ncbi.nlm.nih.gov/pubmed/35288601
http://dx.doi.org/10.1038/s41598-022-08169-1

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