Artificial intelligence-rationalized balanced PPARα/γ dual agonism resets dysregulated macrophage processes in inflammatory bowel disease

A computational platform, Boolean network explorer (BoNE), has recently been developed to infuse AI-enhanced precision into drug discovery; it enables invariant Boolean Implication Networks of disease maps for prioritizing high-value targets. Here we used BoNE to query an Inflammatory Bowel Disease...

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Detalles Bibliográficos
Autores principales: Katkar, Gajanan D., Sayed, Ibrahim M., Anandachar, Mahitha Shree, Castillo, Vanessa, Vidales, Eleadah, Toobian, Daniel, Usmani, Fatima, Sawires, Joseph R., Leriche, Geoffray, Yang, Jerry, Sandborn, William J., Das, Soumita, Sahoo, Debashis, Ghosh, Pradipta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921270/
https://www.ncbi.nlm.nih.gov/pubmed/35288651
http://dx.doi.org/10.1038/s42003-022-03168-4

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