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Immediate complete revascularization showed better outcome in out-of-hospital cardiac arrest survivors with left main or triple-vessel coronary diseases

This study aimed to evaluate the prevalence of left main or triple vessel coronary artery disease (CAD) in comatose out-of-hospital cardiac arrest (OHCA) survivors and assessed their outcome based on the revascularization strategy. This multicenter, retrospective, observational registry-based study...

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Autores principales: Kim, Youn-Jung, Park, Duk-Woo, Kim, Yong Hwan, Choi, Minwoo, Kim, Su Jin, Lee, Gun Tak, Lee, Dong Hun, Lee, Byung Kook, Oh, Joo Suk, Oh, Sang Hoon, Lee, Dong Hoon, Kim, Won Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921273/
https://www.ncbi.nlm.nih.gov/pubmed/35288637
http://dx.doi.org/10.1038/s41598-022-08383-x
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author Kim, Youn-Jung
Park, Duk-Woo
Kim, Yong Hwan
Choi, Minwoo
Kim, Su Jin
Lee, Gun Tak
Lee, Dong Hun
Lee, Byung Kook
Oh, Joo Suk
Oh, Sang Hoon
Lee, Dong Hoon
Kim, Won Young
author_facet Kim, Youn-Jung
Park, Duk-Woo
Kim, Yong Hwan
Choi, Minwoo
Kim, Su Jin
Lee, Gun Tak
Lee, Dong Hun
Lee, Byung Kook
Oh, Joo Suk
Oh, Sang Hoon
Lee, Dong Hoon
Kim, Won Young
author_sort Kim, Youn-Jung
collection PubMed
description This study aimed to evaluate the prevalence of left main or triple vessel coronary artery disease (CAD) in comatose out-of-hospital cardiac arrest (OHCA) survivors and assessed their outcome based on the revascularization strategy. This multicenter, retrospective, observational registry-based study was conducted at 9 Korean tertiary care hospitals. Adult comatose OHCA survivors with left main or triple vessel CAD documented by immediate (≤ 2 h) coronary angiography after return of spontaneous circulation between 2011 and 2019 were included. The primary outcome was neurologically intact survival at 1-month. Among 727 OHCA patients, 150 (25%) had left main or triple vessel CAD and underwent complete (N = 32), incomplete (N = 78), and no immediate (N = 40) revascularization, respectively. The rate of neurologically intact survival at 1 month was significantly different among the groups (53%, 32%, and 23% for complete, incomplete, and no immediate revascularization groups, respectively; P = 0.02). After adjustment using the inverse probability of treatment weighting, complete revascularization was associated with neurologically intact survival at 1 month (odds ratio, 2.635; P = 0.01). Left main or triple vessel CAD is not uncommon in OHCA patients. The complete revascularization was associated with better outcome. Further clinical trials to confirm the best revascularization strategy are needed.
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spelling pubmed-89212732022-03-16 Immediate complete revascularization showed better outcome in out-of-hospital cardiac arrest survivors with left main or triple-vessel coronary diseases Kim, Youn-Jung Park, Duk-Woo Kim, Yong Hwan Choi, Minwoo Kim, Su Jin Lee, Gun Tak Lee, Dong Hun Lee, Byung Kook Oh, Joo Suk Oh, Sang Hoon Lee, Dong Hoon Kim, Won Young Sci Rep Article This study aimed to evaluate the prevalence of left main or triple vessel coronary artery disease (CAD) in comatose out-of-hospital cardiac arrest (OHCA) survivors and assessed their outcome based on the revascularization strategy. This multicenter, retrospective, observational registry-based study was conducted at 9 Korean tertiary care hospitals. Adult comatose OHCA survivors with left main or triple vessel CAD documented by immediate (≤ 2 h) coronary angiography after return of spontaneous circulation between 2011 and 2019 were included. The primary outcome was neurologically intact survival at 1-month. Among 727 OHCA patients, 150 (25%) had left main or triple vessel CAD and underwent complete (N = 32), incomplete (N = 78), and no immediate (N = 40) revascularization, respectively. The rate of neurologically intact survival at 1 month was significantly different among the groups (53%, 32%, and 23% for complete, incomplete, and no immediate revascularization groups, respectively; P = 0.02). After adjustment using the inverse probability of treatment weighting, complete revascularization was associated with neurologically intact survival at 1 month (odds ratio, 2.635; P = 0.01). Left main or triple vessel CAD is not uncommon in OHCA patients. The complete revascularization was associated with better outcome. Further clinical trials to confirm the best revascularization strategy are needed. Nature Publishing Group UK 2022-03-14 /pmc/articles/PMC8921273/ /pubmed/35288637 http://dx.doi.org/10.1038/s41598-022-08383-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kim, Youn-Jung
Park, Duk-Woo
Kim, Yong Hwan
Choi, Minwoo
Kim, Su Jin
Lee, Gun Tak
Lee, Dong Hun
Lee, Byung Kook
Oh, Joo Suk
Oh, Sang Hoon
Lee, Dong Hoon
Kim, Won Young
Immediate complete revascularization showed better outcome in out-of-hospital cardiac arrest survivors with left main or triple-vessel coronary diseases
title Immediate complete revascularization showed better outcome in out-of-hospital cardiac arrest survivors with left main or triple-vessel coronary diseases
title_full Immediate complete revascularization showed better outcome in out-of-hospital cardiac arrest survivors with left main or triple-vessel coronary diseases
title_fullStr Immediate complete revascularization showed better outcome in out-of-hospital cardiac arrest survivors with left main or triple-vessel coronary diseases
title_full_unstemmed Immediate complete revascularization showed better outcome in out-of-hospital cardiac arrest survivors with left main or triple-vessel coronary diseases
title_short Immediate complete revascularization showed better outcome in out-of-hospital cardiac arrest survivors with left main or triple-vessel coronary diseases
title_sort immediate complete revascularization showed better outcome in out-of-hospital cardiac arrest survivors with left main or triple-vessel coronary diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921273/
https://www.ncbi.nlm.nih.gov/pubmed/35288637
http://dx.doi.org/10.1038/s41598-022-08383-x
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