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Persistent post-concussive syndrome in children after mild traumatic brain injury is prevalent and vastly underdiagnosed

Data on epidemiology and prognosticators of persistent post-concussion syndrome (PPCS) after mild traumatic brain injury (mTBI) in the pediatric population is scarce. The aim of this study was to evaluate the prevalence of PPCS in children after mTBI and to identify clinical variables in children wh...

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Autores principales: Fried, Eli, Balla, Uri, Catalogna, Merav, Kozer, Eran, Oren-Amit, Adi, Hadanny, Amir, Efrati, Shai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921281/
https://www.ncbi.nlm.nih.gov/pubmed/35288616
http://dx.doi.org/10.1038/s41598-022-08302-0
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author Fried, Eli
Balla, Uri
Catalogna, Merav
Kozer, Eran
Oren-Amit, Adi
Hadanny, Amir
Efrati, Shai
author_facet Fried, Eli
Balla, Uri
Catalogna, Merav
Kozer, Eran
Oren-Amit, Adi
Hadanny, Amir
Efrati, Shai
author_sort Fried, Eli
collection PubMed
description Data on epidemiology and prognosticators of persistent post-concussion syndrome (PPCS) after mild traumatic brain injury (mTBI) in the pediatric population is scarce. The aim of this study was to evaluate the prevalence of PPCS in children after mTBI and to identify clinical variables in children who are at high risk for developing PPCS. A multicenter, retrospective matched cohort in which PPCS symptoms were evaluated in children 8–15-year-old, 6–60 months after being admitted to the emergency department because of mTBI. The control group included children admitted to the emergency department because of uncomplicated distal radius fractures. The children's guardians were interviewed for the presence of PPCS symptoms using the "Rivermead Post-Concussion Questionnaire". A multivariable logistic regression model was used to identify predictors of PPCS. Two-hundred and five children were included in the mTBI group and 205 in the control. The median time from the injury was 33.5 months in the mTBI group and 33.8 in the control. The prevalence of PPCS in the mTBI group was 25.3% and PPCS like symptoms in the control was 2.4%, p < 0.001. Within the 6–60 months period, the PPCS prevalence was not influenced by the time that elapsed from the injury. In the mTBI group, motor vehicle accidents and adolescence were found to be risk factors for PPCS. PPCS is underdiagnosed in the pediatric population and 25% of children admitted to the ED due to mTBI may suffer from PPCS. Screening guidelines should be implemented to identify and properly treat these children.
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spelling pubmed-89212812022-03-16 Persistent post-concussive syndrome in children after mild traumatic brain injury is prevalent and vastly underdiagnosed Fried, Eli Balla, Uri Catalogna, Merav Kozer, Eran Oren-Amit, Adi Hadanny, Amir Efrati, Shai Sci Rep Article Data on epidemiology and prognosticators of persistent post-concussion syndrome (PPCS) after mild traumatic brain injury (mTBI) in the pediatric population is scarce. The aim of this study was to evaluate the prevalence of PPCS in children after mTBI and to identify clinical variables in children who are at high risk for developing PPCS. A multicenter, retrospective matched cohort in which PPCS symptoms were evaluated in children 8–15-year-old, 6–60 months after being admitted to the emergency department because of mTBI. The control group included children admitted to the emergency department because of uncomplicated distal radius fractures. The children's guardians were interviewed for the presence of PPCS symptoms using the "Rivermead Post-Concussion Questionnaire". A multivariable logistic regression model was used to identify predictors of PPCS. Two-hundred and five children were included in the mTBI group and 205 in the control. The median time from the injury was 33.5 months in the mTBI group and 33.8 in the control. The prevalence of PPCS in the mTBI group was 25.3% and PPCS like symptoms in the control was 2.4%, p < 0.001. Within the 6–60 months period, the PPCS prevalence was not influenced by the time that elapsed from the injury. In the mTBI group, motor vehicle accidents and adolescence were found to be risk factors for PPCS. PPCS is underdiagnosed in the pediatric population and 25% of children admitted to the ED due to mTBI may suffer from PPCS. Screening guidelines should be implemented to identify and properly treat these children. Nature Publishing Group UK 2022-03-14 /pmc/articles/PMC8921281/ /pubmed/35288616 http://dx.doi.org/10.1038/s41598-022-08302-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Fried, Eli
Balla, Uri
Catalogna, Merav
Kozer, Eran
Oren-Amit, Adi
Hadanny, Amir
Efrati, Shai
Persistent post-concussive syndrome in children after mild traumatic brain injury is prevalent and vastly underdiagnosed
title Persistent post-concussive syndrome in children after mild traumatic brain injury is prevalent and vastly underdiagnosed
title_full Persistent post-concussive syndrome in children after mild traumatic brain injury is prevalent and vastly underdiagnosed
title_fullStr Persistent post-concussive syndrome in children after mild traumatic brain injury is prevalent and vastly underdiagnosed
title_full_unstemmed Persistent post-concussive syndrome in children after mild traumatic brain injury is prevalent and vastly underdiagnosed
title_short Persistent post-concussive syndrome in children after mild traumatic brain injury is prevalent and vastly underdiagnosed
title_sort persistent post-concussive syndrome in children after mild traumatic brain injury is prevalent and vastly underdiagnosed
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921281/
https://www.ncbi.nlm.nih.gov/pubmed/35288616
http://dx.doi.org/10.1038/s41598-022-08302-0
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