Inhibition of STAT3(Y705) phosphorylation by Stattic suppresses proliferation and induces mitochondrial-dependent apoptosis in pancreatic cancer cells

Patients with pancreatic cancer (PC) show dismal prognosis and high mortality. The development of PC is associated with the overactivation of STAT3. Here, we have determined that the non-peptide small molecule Stattic inhibits PC development by targeting STAT3. In vitro, Stattic treatment time- and...

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Detalles Bibliográficos
Autores principales: Guo, Hangcheng, Xiao, Yanyi, Yuan, Ziwei, Yang, Xuejia, Chen, Jiawei, Chen, Chaoyue, Wang, Mengsi, Xie, Lili, Chen, Qinbo, Tong, Yu, Zhang, Qiyu, Bai, Yongheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921333/
https://www.ncbi.nlm.nih.gov/pubmed/35288541
http://dx.doi.org/10.1038/s41420-022-00922-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921333/
https://www.ncbi.nlm.nih.gov/pubmed/35288541
http://dx.doi.org/10.1038/s41420-022-00922-9

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