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N6-Methyladenosine Regulators Promote Malignant Progression of Gastric Adenocarcinoma
N6-methyladenosine (m6A) RNA methylation is dynamically and reversibly regulated by methyltransferases, binding proteins, and demethylases. The restoration of m6A to adenosine could result in demethylation modifications. Abnormalities in m6A epigenetic modifications in cancer are of increasing inter...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921461/ https://www.ncbi.nlm.nih.gov/pubmed/35299934 http://dx.doi.org/10.3389/fonc.2021.726018 |
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author | Zhao, Yibin Yan, Xiao Wang, Yu Zhou, Juan Yu, Yang |
author_facet | Zhao, Yibin Yan, Xiao Wang, Yu Zhou, Juan Yu, Yang |
author_sort | Zhao, Yibin |
collection | PubMed |
description | N6-methyladenosine (m6A) RNA methylation is dynamically and reversibly regulated by methyltransferases, binding proteins, and demethylases. The restoration of m6A to adenosine could result in demethylation modifications. Abnormalities in m6A epigenetic modifications in cancer are of increasing interest in recent years. According to the progression and prognostic performance of m6A epigenetic modifications in gastric adenocarcinoma (STAD), this study comprehensively analyzed the m6A modification patterns of gastric adenocarcinoma specimens in The Cancer Genome Atlas (TCGA) database based on 20 m6A regulators. Here, we found that 20 m6A RNA methylation regulators were high-expressed in gastric adenocarcinoma. m6A RNA methylation regulators were closely associated with pT staging of gastric cancer. Based on such findings, we developed a prognostic model using four m6A RNA methylation regulators (IGF2BP1, RBM15, FTO, ALKBH5), and the FTO was confirmed as an independent prognostic marker. |
format | Online Article Text |
id | pubmed-8921461 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89214612022-03-16 N6-Methyladenosine Regulators Promote Malignant Progression of Gastric Adenocarcinoma Zhao, Yibin Yan, Xiao Wang, Yu Zhou, Juan Yu, Yang Front Oncol Oncology N6-methyladenosine (m6A) RNA methylation is dynamically and reversibly regulated by methyltransferases, binding proteins, and demethylases. The restoration of m6A to adenosine could result in demethylation modifications. Abnormalities in m6A epigenetic modifications in cancer are of increasing interest in recent years. According to the progression and prognostic performance of m6A epigenetic modifications in gastric adenocarcinoma (STAD), this study comprehensively analyzed the m6A modification patterns of gastric adenocarcinoma specimens in The Cancer Genome Atlas (TCGA) database based on 20 m6A regulators. Here, we found that 20 m6A RNA methylation regulators were high-expressed in gastric adenocarcinoma. m6A RNA methylation regulators were closely associated with pT staging of gastric cancer. Based on such findings, we developed a prognostic model using four m6A RNA methylation regulators (IGF2BP1, RBM15, FTO, ALKBH5), and the FTO was confirmed as an independent prognostic marker. Frontiers Media S.A. 2022-03-01 /pmc/articles/PMC8921461/ /pubmed/35299934 http://dx.doi.org/10.3389/fonc.2021.726018 Text en Copyright © 2022 Zhao, Yan, Wang, Zhou and Yu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Zhao, Yibin Yan, Xiao Wang, Yu Zhou, Juan Yu, Yang N6-Methyladenosine Regulators Promote Malignant Progression of Gastric Adenocarcinoma |
title | N6-Methyladenosine Regulators Promote Malignant Progression of Gastric Adenocarcinoma |
title_full | N6-Methyladenosine Regulators Promote Malignant Progression of Gastric Adenocarcinoma |
title_fullStr | N6-Methyladenosine Regulators Promote Malignant Progression of Gastric Adenocarcinoma |
title_full_unstemmed | N6-Methyladenosine Regulators Promote Malignant Progression of Gastric Adenocarcinoma |
title_short | N6-Methyladenosine Regulators Promote Malignant Progression of Gastric Adenocarcinoma |
title_sort | n6-methyladenosine regulators promote malignant progression of gastric adenocarcinoma |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921461/ https://www.ncbi.nlm.nih.gov/pubmed/35299934 http://dx.doi.org/10.3389/fonc.2021.726018 |
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