BRCA1 and Breast Cancer: Molecular Mechanisms and Therapeutic Strategies

Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene, which is mainly involved in the repair of DNA damage, cell cycle regulation, maintenance of genome stability, and other important physiological processes. Mutations or defects in the BRCA1 gene significantly increase the risk of...

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Autores principales: Fu, Xiaoyu, Tan, Wei, Song, Qibin, Pei, Huadong, Li, Juanjuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921524/
https://www.ncbi.nlm.nih.gov/pubmed/35300412
http://dx.doi.org/10.3389/fcell.2022.813457
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author Fu, Xiaoyu
Tan, Wei
Song, Qibin
Pei, Huadong
Li, Juanjuan
author_facet Fu, Xiaoyu
Tan, Wei
Song, Qibin
Pei, Huadong
Li, Juanjuan
author_sort Fu, Xiaoyu
collection PubMed
description Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene, which is mainly involved in the repair of DNA damage, cell cycle regulation, maintenance of genome stability, and other important physiological processes. Mutations or defects in the BRCA1 gene significantly increase the risk of breast, ovarian, prostate, and other cancers in carriers. In this review, we summarized the molecular functions and regulation of BRCA1 and discussed recent insights into the detection and treatment of BRCA1 mutated breast cancer.
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spelling pubmed-89215242022-03-16 BRCA1 and Breast Cancer: Molecular Mechanisms and Therapeutic Strategies Fu, Xiaoyu Tan, Wei Song, Qibin Pei, Huadong Li, Juanjuan Front Cell Dev Biol Cell and Developmental Biology Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene, which is mainly involved in the repair of DNA damage, cell cycle regulation, maintenance of genome stability, and other important physiological processes. Mutations or defects in the BRCA1 gene significantly increase the risk of breast, ovarian, prostate, and other cancers in carriers. In this review, we summarized the molecular functions and regulation of BRCA1 and discussed recent insights into the detection and treatment of BRCA1 mutated breast cancer. Frontiers Media S.A. 2022-03-01 /pmc/articles/PMC8921524/ /pubmed/35300412 http://dx.doi.org/10.3389/fcell.2022.813457 Text en Copyright © 2022 Fu, Tan, Song, Pei and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Fu, Xiaoyu
Tan, Wei
Song, Qibin
Pei, Huadong
Li, Juanjuan
BRCA1 and Breast Cancer: Molecular Mechanisms and Therapeutic Strategies
title BRCA1 and Breast Cancer: Molecular Mechanisms and Therapeutic Strategies
title_full BRCA1 and Breast Cancer: Molecular Mechanisms and Therapeutic Strategies
title_fullStr BRCA1 and Breast Cancer: Molecular Mechanisms and Therapeutic Strategies
title_full_unstemmed BRCA1 and Breast Cancer: Molecular Mechanisms and Therapeutic Strategies
title_short BRCA1 and Breast Cancer: Molecular Mechanisms and Therapeutic Strategies
title_sort brca1 and breast cancer: molecular mechanisms and therapeutic strategies
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921524/
https://www.ncbi.nlm.nih.gov/pubmed/35300412
http://dx.doi.org/10.3389/fcell.2022.813457
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