Ginseng polysaccharides alter the gut microbiota and kynurenine/tryptophan ratio, potentiating the antitumour effect of antiprogrammed cell death 1/programmed cell death ligand 1 (anti-PD-1/PD-L1) immunotherapy

OBJECTIVE: Programmed death 1 and its ligand 1 (PD-1/PD-L1) immunotherapy is promising for late-stage lung cancer treatment, however, the response rate needs to be improved. Gut microbiota plays a crucial role in immunotherapy sensitisation and Panax ginseng has been shown to possess immunomodulator...

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Detalles Bibliográficos
Autores principales: Huang, Jumin, Liu, Di, Wang, Yuwei, Liu, Liang, Li, Jian, Yuan, Jing, Jiang, Zhihong, Jiang, Zebo, Hsiao, WL Wendy, Liu, Haizhou, Khan, Imran, Xie, Ying, Wu, Jianlin, Xie, Yajia, Zhang, Yizhong, Fu, Yu, Liao, Junyi, Wang, Wenjun, Lai, Huanling, Shi, Axi, Cai, Jun, Luo, Lianxiang, Li, Runze, Yao, Xiaojun, Fan, Xingxing, Wu, Qibiao, Liu, Zhongqiu, Yan, Peiyu, Lu, Jingguang, Yang, Mingrong, Wang, Lin, Cao, Yabing, Wei, Hong, Leung, Elaine Lai-Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Gut Microbiota
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921579/
https://www.ncbi.nlm.nih.gov/pubmed/34006584
http://dx.doi.org/10.1136/gutjnl-2020-321031

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