Blocking GM-CSF receptor α with mavrilimumab reduces infiltrating cells, pro-inflammatory markers and neoangiogenesis in ex vivo cultured arteries from patients with giant cell arteritis

BACKGROUND: Effective and safe therapies are needed for the treatment of patients with giant cell arteritis (GCA). Emerging as a key cytokine in inflammation, granulocyte-macrophage colony stimulating factor (GM-CSF) may play a role in promoting inflammation in GCA. OBJECTIVES: To investigate expres...

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Detalles Bibliográficos
Autores principales: Corbera-Bellalta, Marc, Alba-Rovira, Roser, Muralidharan, Sujatha, Espígol-Frigolé, Georgina, Ríos-Garcés, Roberto, Marco-Hernández, Javier, Denuc, Amanda, Kamberovic, Farah, Pérez-Galán, Patricia, Joseph, Alexandra, D’Andrea, Annalisa, Bondensgaard, Kent, Cid, Maria C, Paolini, John F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Vasculitis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921590/
https://www.ncbi.nlm.nih.gov/pubmed/35045965
http://dx.doi.org/10.1136/annrheumdis-2021-220873

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921590/
https://www.ncbi.nlm.nih.gov/pubmed/35045965
http://dx.doi.org/10.1136/annrheumdis-2021-220873

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