Combined Machine Learning and GRID-Independent Molecular Descriptor (GRIND) Models to Probe the Activity Profiles of 5-Lipoxygenase Activating Protein Inhibitors

Leukotrienes (LTs) are pro-inflammatory lipid mediators derived from arachidonic acid (AA), and their high production has been reported in multiple allergic, autoimmune, and cardiovascular disorders. The biological synthesis of leukotrienes is instigated by transfer of AA to 5-lipoxygenase (5-LO) vi...

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Detalles Bibliográficos
Autores principales: Khan, Hafiza Aliza, Jabeen, Ishrat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921698/
https://www.ncbi.nlm.nih.gov/pubmed/35300294
http://dx.doi.org/10.3389/fphar.2022.825741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921698/
https://www.ncbi.nlm.nih.gov/pubmed/35300294
http://dx.doi.org/10.3389/fphar.2022.825741

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