Cargando…

Mechanisms of action of radon therapy on cytokine levels in normal mice and rheumatoid arthritis mouse model

The typical indication of radon therapy is rheumatoid arthritis. Although there are several reports that radon therapy has regulation effects on Th17 cells, there has been no study reporting that radon inhalation affects the immune balance among Th1, Th2, and Th17. The purpose of this study is to ex...

Descripción completa

Detalles Bibliográficos
Autores principales: Kataoka, Takahiro, Naoe, Shota, Murakami, Kaito, Yukimine, Ryohei, Fujimoto, Yuki, Kanzaki, Norie, Sakoda, Akihiro, Mitsunobu, Fumihiro, Yamaoka, Kiyonori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: the Society for Free Radical Research Japan 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921724/
https://www.ncbi.nlm.nih.gov/pubmed/35400822
http://dx.doi.org/10.3164/jcbn.21-91
_version_ 1784669382761250816
author Kataoka, Takahiro
Naoe, Shota
Murakami, Kaito
Yukimine, Ryohei
Fujimoto, Yuki
Kanzaki, Norie
Sakoda, Akihiro
Mitsunobu, Fumihiro
Yamaoka, Kiyonori
author_facet Kataoka, Takahiro
Naoe, Shota
Murakami, Kaito
Yukimine, Ryohei
Fujimoto, Yuki
Kanzaki, Norie
Sakoda, Akihiro
Mitsunobu, Fumihiro
Yamaoka, Kiyonori
author_sort Kataoka, Takahiro
collection PubMed
description The typical indication of radon therapy is rheumatoid arthritis. Although there are several reports that radon therapy has regulation effects on Th17 cells, there has been no study reporting that radon inhalation affects the immune balance among Th1, Th2, and Th17. The purpose of this study is to examine the cytokine changes after radon inhalation. BALB/c mice inhaled radon at 2,000 Bq/m(3) for 2 or 4 weeks. SKG/Jcl mice inhaled radon at 2,000 Bq/m(3) for 4 weeks after zymosan administration. The results showed that radon inhalation for 4 weeks activated the immune response of Th1, Th2, and Th17. Moreover, the balance among them was not lost by radon inhalation. Radon inhalation for 4 weeks decreased superoxide dismutase activity and increased catalase activity in spleen. These findings suggest that an imbalance of oxidative stress may contribute to activate the immune response. Although zymosan administration activated Th17 immune response and decreased Th1 and Th2 immune response in SKG/Jcl mice, most cytokines related to Th1, Th2, and Th17 approached the normal level by radon inhalation. These findings suggested that radon inhalation has a different action between SKG/Jcl mice and normal BABL/c mice. This may indicate that radon inhalation has an immunomodulation function.
format Online
Article
Text
id pubmed-8921724
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher the Society for Free Radical Research Japan
record_format MEDLINE/PubMed
spelling pubmed-89217242022-04-07 Mechanisms of action of radon therapy on cytokine levels in normal mice and rheumatoid arthritis mouse model Kataoka, Takahiro Naoe, Shota Murakami, Kaito Yukimine, Ryohei Fujimoto, Yuki Kanzaki, Norie Sakoda, Akihiro Mitsunobu, Fumihiro Yamaoka, Kiyonori J Clin Biochem Nutr Original Article The typical indication of radon therapy is rheumatoid arthritis. Although there are several reports that radon therapy has regulation effects on Th17 cells, there has been no study reporting that radon inhalation affects the immune balance among Th1, Th2, and Th17. The purpose of this study is to examine the cytokine changes after radon inhalation. BALB/c mice inhaled radon at 2,000 Bq/m(3) for 2 or 4 weeks. SKG/Jcl mice inhaled radon at 2,000 Bq/m(3) for 4 weeks after zymosan administration. The results showed that radon inhalation for 4 weeks activated the immune response of Th1, Th2, and Th17. Moreover, the balance among them was not lost by radon inhalation. Radon inhalation for 4 weeks decreased superoxide dismutase activity and increased catalase activity in spleen. These findings suggest that an imbalance of oxidative stress may contribute to activate the immune response. Although zymosan administration activated Th17 immune response and decreased Th1 and Th2 immune response in SKG/Jcl mice, most cytokines related to Th1, Th2, and Th17 approached the normal level by radon inhalation. These findings suggested that radon inhalation has a different action between SKG/Jcl mice and normal BABL/c mice. This may indicate that radon inhalation has an immunomodulation function. the Society for Free Radical Research Japan 2022-03 2021-11-26 /pmc/articles/PMC8921724/ /pubmed/35400822 http://dx.doi.org/10.3164/jcbn.21-91 Text en Copyright © 2022 JCBN https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Original Article
Kataoka, Takahiro
Naoe, Shota
Murakami, Kaito
Yukimine, Ryohei
Fujimoto, Yuki
Kanzaki, Norie
Sakoda, Akihiro
Mitsunobu, Fumihiro
Yamaoka, Kiyonori
Mechanisms of action of radon therapy on cytokine levels in normal mice and rheumatoid arthritis mouse model
title Mechanisms of action of radon therapy on cytokine levels in normal mice and rheumatoid arthritis mouse model
title_full Mechanisms of action of radon therapy on cytokine levels in normal mice and rheumatoid arthritis mouse model
title_fullStr Mechanisms of action of radon therapy on cytokine levels in normal mice and rheumatoid arthritis mouse model
title_full_unstemmed Mechanisms of action of radon therapy on cytokine levels in normal mice and rheumatoid arthritis mouse model
title_short Mechanisms of action of radon therapy on cytokine levels in normal mice and rheumatoid arthritis mouse model
title_sort mechanisms of action of radon therapy on cytokine levels in normal mice and rheumatoid arthritis mouse model
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921724/
https://www.ncbi.nlm.nih.gov/pubmed/35400822
http://dx.doi.org/10.3164/jcbn.21-91
work_keys_str_mv AT kataokatakahiro mechanismsofactionofradontherapyoncytokinelevelsinnormalmiceandrheumatoidarthritismousemodel
AT naoeshota mechanismsofactionofradontherapyoncytokinelevelsinnormalmiceandrheumatoidarthritismousemodel
AT murakamikaito mechanismsofactionofradontherapyoncytokinelevelsinnormalmiceandrheumatoidarthritismousemodel
AT yukimineryohei mechanismsofactionofradontherapyoncytokinelevelsinnormalmiceandrheumatoidarthritismousemodel
AT fujimotoyuki mechanismsofactionofradontherapyoncytokinelevelsinnormalmiceandrheumatoidarthritismousemodel
AT kanzakinorie mechanismsofactionofradontherapyoncytokinelevelsinnormalmiceandrheumatoidarthritismousemodel
AT sakodaakihiro mechanismsofactionofradontherapyoncytokinelevelsinnormalmiceandrheumatoidarthritismousemodel
AT mitsunobufumihiro mechanismsofactionofradontherapyoncytokinelevelsinnormalmiceandrheumatoidarthritismousemodel
AT yamaokakiyonori mechanismsofactionofradontherapyoncytokinelevelsinnormalmiceandrheumatoidarthritismousemodel