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Lonafarnib Inhibits Farnesyltransferase via Suppressing ERK Signaling Pathway to Prevent Osteoclastogenesis in Titanium Particle-Induced Osteolysis

Wear debris after total joint arthroplasty can attract the recruitment of macrophages, which release pro-inflammatory substances, triggering the activation of osteoclasts, thereby leading to periprosthetic osteolysis (PPOL) and aseptic loosening. However, the development of pharmacological strategie...

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Detalles Bibliográficos
Autores principales:	Huang, Linke, Chen, Weiwei, Wei, Linhua, Su, Yuangang, Liang, Jiamin, Lian, Haoyu, Wang, Hui, Long, Feng, Yang, Fan, Gao, Shiyao, Tan, Zhen, Xu, Jiake, Zhao, Jinmin, Liu, Qian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921770/ https://www.ncbi.nlm.nih.gov/pubmed/35300293 http://dx.doi.org/10.3389/fphar.2022.848152

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