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Two Compact Cas9 Ortholog-Based Cytosine Base Editors Expand the DNA Targeting Scope and Applications In Vitro and In Vivo

CRISPR/Cas9-based base editing tools enable precise genomic installation and hold great promise for gene therapy, whereas the big size of Cas9 nucleases and its reliability on specific protospacer adjacent motif (PAM) sequences as well as target site preferences restrict the extensive applications o...

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Detalles Bibliográficos
Autores principales:	Wu, Susu, Li, Liping, Li, Min, Sun, Shiyu, Zhao, Yuting, Xue, Xiaowen, Chen, Feiyu, Zhong, Jingli, Guo, Junfan, Qu, Qianhui, Wang, Xiongjun, Liu, Zhen, Qiao, Yunbo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921874/ https://www.ncbi.nlm.nih.gov/pubmed/35300420 http://dx.doi.org/10.3389/fcell.2022.809922

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