Cargando…

A novel intra-ventricular assist device enhances cardiac performance in normal and acutely failing isolated porcine hearts

BACKGROUND: We recently demonstrated that a novel intra-ventricular membrane pump (IVMP) was able to increase the pump function of isolated beating porcine hearts. In follow-up, we now investigated the impact of the IVMP on myocardial oxygen consumption and total mechanical efficiency (TME) and asse...

Descripción completa

Detalles Bibliográficos
Autores principales: van Dort, Daniël IM, Thannhauser, Jos, Morshuis, Wim J, Geuzebroek, Guillaume SC, Duncker, Dirk J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921884/
https://www.ncbi.nlm.nih.gov/pubmed/33818165
http://dx.doi.org/10.1177/03913988211003912
_version_ 1784669408658980864
author van Dort, Daniël IM
Thannhauser, Jos
Morshuis, Wim J
Geuzebroek, Guillaume SC
Duncker, Dirk J
author_facet van Dort, Daniël IM
Thannhauser, Jos
Morshuis, Wim J
Geuzebroek, Guillaume SC
Duncker, Dirk J
author_sort van Dort, Daniël IM
collection PubMed
description BACKGROUND: We recently demonstrated that a novel intra-ventricular membrane pump (IVMP) was able to increase the pump function of isolated beating porcine hearts. In follow-up, we now investigated the impact of the IVMP on myocardial oxygen consumption and total mechanical efficiency (TME) and assessed the effect of IVMP-support in acutely failing hearts. METHODS: In 10 ex vivo beating porcine hearts, we studied hemodynamic parameters, as well as arterial and coronary venous oxygen content. We assessed cardiac power (CP), myocardial oxygen consumption (MVO(2)), and TME (CP divided by MVO(2)) under baseline conditions and during IVMP-support. Additionally, five isolated hearts were subjected to global hypoxia to investigate the effects of IVMP-support on CP under conditions of acute heart failure. RESULTS: Under physiological conditions, baseline CP was 0.36 ± 0.10 W, which increased to 0.65 ± 0.16 W during IVMP-support (increase of 85% ± 24, p < 0.001). This was accompanied by an increase in MVO2 from 18.6 ± 6.2 ml/min at baseline, to 22.3 ± 5.0 ml/min during IVMP-support (+26 ± 31%, p = 0.005). As a result, TME (%) increased from 5.9 ± 1.2 to 8.8 ± 1.8 (50 ± 22% increase, p < 0.001). Acute hypoxia-induced cardiac pump failure reduced CP by 35 ± 6%, which was fully restored to baseline levels during IVMP-support in all hearts. CONCLUSION: IVMP-support improved mechanical efficiency under physiological conditions, as the marked increase in cardiac performance only resulted in a modest increase in oxygen consumption. Moreover, the IVMP rapidly restored cardiac performance under conditions of acute pump failure. These observations warrant further study, to evaluate the effects of IVMP-support in in vivo animal models of acute cardiac pump failure.
format Online
Article
Text
id pubmed-8921884
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-89218842022-03-16 A novel intra-ventricular assist device enhances cardiac performance in normal and acutely failing isolated porcine hearts van Dort, Daniël IM Thannhauser, Jos Morshuis, Wim J Geuzebroek, Guillaume SC Duncker, Dirk J Int J Artif Organs Original Research Articles BACKGROUND: We recently demonstrated that a novel intra-ventricular membrane pump (IVMP) was able to increase the pump function of isolated beating porcine hearts. In follow-up, we now investigated the impact of the IVMP on myocardial oxygen consumption and total mechanical efficiency (TME) and assessed the effect of IVMP-support in acutely failing hearts. METHODS: In 10 ex vivo beating porcine hearts, we studied hemodynamic parameters, as well as arterial and coronary venous oxygen content. We assessed cardiac power (CP), myocardial oxygen consumption (MVO(2)), and TME (CP divided by MVO(2)) under baseline conditions and during IVMP-support. Additionally, five isolated hearts were subjected to global hypoxia to investigate the effects of IVMP-support on CP under conditions of acute heart failure. RESULTS: Under physiological conditions, baseline CP was 0.36 ± 0.10 W, which increased to 0.65 ± 0.16 W during IVMP-support (increase of 85% ± 24, p < 0.001). This was accompanied by an increase in MVO2 from 18.6 ± 6.2 ml/min at baseline, to 22.3 ± 5.0 ml/min during IVMP-support (+26 ± 31%, p = 0.005). As a result, TME (%) increased from 5.9 ± 1.2 to 8.8 ± 1.8 (50 ± 22% increase, p < 0.001). Acute hypoxia-induced cardiac pump failure reduced CP by 35 ± 6%, which was fully restored to baseline levels during IVMP-support in all hearts. CONCLUSION: IVMP-support improved mechanical efficiency under physiological conditions, as the marked increase in cardiac performance only resulted in a modest increase in oxygen consumption. Moreover, the IVMP rapidly restored cardiac performance under conditions of acute pump failure. These observations warrant further study, to evaluate the effects of IVMP-support in in vivo animal models of acute cardiac pump failure. SAGE Publications 2021-04-05 2022-04 /pmc/articles/PMC8921884/ /pubmed/33818165 http://dx.doi.org/10.1177/03913988211003912 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research Articles
van Dort, Daniël IM
Thannhauser, Jos
Morshuis, Wim J
Geuzebroek, Guillaume SC
Duncker, Dirk J
A novel intra-ventricular assist device enhances cardiac performance in normal and acutely failing isolated porcine hearts
title A novel intra-ventricular assist device enhances cardiac performance in normal and acutely failing isolated porcine hearts
title_full A novel intra-ventricular assist device enhances cardiac performance in normal and acutely failing isolated porcine hearts
title_fullStr A novel intra-ventricular assist device enhances cardiac performance in normal and acutely failing isolated porcine hearts
title_full_unstemmed A novel intra-ventricular assist device enhances cardiac performance in normal and acutely failing isolated porcine hearts
title_short A novel intra-ventricular assist device enhances cardiac performance in normal and acutely failing isolated porcine hearts
title_sort novel intra-ventricular assist device enhances cardiac performance in normal and acutely failing isolated porcine hearts
topic Original Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921884/
https://www.ncbi.nlm.nih.gov/pubmed/33818165
http://dx.doi.org/10.1177/03913988211003912
work_keys_str_mv AT vandortdanielim anovelintraventricularassistdeviceenhancescardiacperformanceinnormalandacutelyfailingisolatedporcinehearts
AT thannhauserjos anovelintraventricularassistdeviceenhancescardiacperformanceinnormalandacutelyfailingisolatedporcinehearts
AT morshuiswimj anovelintraventricularassistdeviceenhancescardiacperformanceinnormalandacutelyfailingisolatedporcinehearts
AT geuzebroekguillaumesc anovelintraventricularassistdeviceenhancescardiacperformanceinnormalandacutelyfailingisolatedporcinehearts
AT dunckerdirkj anovelintraventricularassistdeviceenhancescardiacperformanceinnormalandacutelyfailingisolatedporcinehearts
AT vandortdanielim novelintraventricularassistdeviceenhancescardiacperformanceinnormalandacutelyfailingisolatedporcinehearts
AT thannhauserjos novelintraventricularassistdeviceenhancescardiacperformanceinnormalandacutelyfailingisolatedporcinehearts
AT morshuiswimj novelintraventricularassistdeviceenhancescardiacperformanceinnormalandacutelyfailingisolatedporcinehearts
AT geuzebroekguillaumesc novelintraventricularassistdeviceenhancescardiacperformanceinnormalandacutelyfailingisolatedporcinehearts
AT dunckerdirkj novelintraventricularassistdeviceenhancescardiacperformanceinnormalandacutelyfailingisolatedporcinehearts