Primary Sclerosing Cholangitis Complicated with Aphthoid Colitis Difficult to Diagnose from IgG4-Related Sclerosing Cholangitis

A 19-year-old man visited our hospital because of diarrhea and blood and liver dysfunction. Magnetic and endoscopic retrograde cholangiography revealed diffuse narrowing of the common biliary tract and intrahepatic biliary tract. A biopsy specimen from the narrowed area of the common biliary tract r...

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Autores principales: Imai, Jin, Ichikawa, Hitoshi, Kaneko, Motoki, Ito, Hiroyuki, Takashimizu, Shinji, Shirai, Takayuki, Tajiri, Takuma, Watanabe, Norihito, Suzuki, Hidekazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2022
Materias:
Single Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921940/
https://www.ncbi.nlm.nih.gov/pubmed/35350672
http://dx.doi.org/10.1159/000521538
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author Imai, Jin
Ichikawa, Hitoshi
Kaneko, Motoki
Ito, Hiroyuki
Takashimizu, Shinji
Shirai, Takayuki
Tajiri, Takuma
Watanabe, Norihito
Suzuki, Hidekazu
author_facet Imai, Jin
Ichikawa, Hitoshi
Kaneko, Motoki
Ito, Hiroyuki
Takashimizu, Shinji
Shirai, Takayuki
Tajiri, Takuma
Watanabe, Norihito
Suzuki, Hidekazu
author_sort Imai, Jin
collection PubMed
description A 19-year-old man visited our hospital because of diarrhea and blood and liver dysfunction. Magnetic and endoscopic retrograde cholangiography revealed diffuse narrowing of the common biliary tract and intrahepatic biliary tract. A biopsy specimen from the narrowed area of the common biliary tract revealed IgG4-related sclerosing cholangitis (IgG4-SC). Colonoscopy showed multiple aphthoid colitis. He was treated with corticosteroids, and the levels of hepatobiliary enzymes, IgG, and IgG4 gradually decreased. This is an extremely rare case of colitis in which the patient had a phenotype of sclerosing cholangitis similar to IgG4-SC, which was finally diagnosed as primary sclerosing cholangitis.
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spelling pubmed-89219402022-03-28 Primary Sclerosing Cholangitis Complicated with Aphthoid Colitis Difficult to Diagnose from IgG4-Related Sclerosing Cholangitis Imai, Jin Ichikawa, Hitoshi Kaneko, Motoki Ito, Hiroyuki Takashimizu, Shinji Shirai, Takayuki Tajiri, Takuma Watanabe, Norihito Suzuki, Hidekazu Case Rep Gastroenterol Single Case A 19-year-old man visited our hospital because of diarrhea and blood and liver dysfunction. Magnetic and endoscopic retrograde cholangiography revealed diffuse narrowing of the common biliary tract and intrahepatic biliary tract. A biopsy specimen from the narrowed area of the common biliary tract revealed IgG4-related sclerosing cholangitis (IgG4-SC). Colonoscopy showed multiple aphthoid colitis. He was treated with corticosteroids, and the levels of hepatobiliary enzymes, IgG, and IgG4 gradually decreased. This is an extremely rare case of colitis in which the patient had a phenotype of sclerosing cholangitis similar to IgG4-SC, which was finally diagnosed as primary sclerosing cholangitis. S. Karger AG 2022-02-07 /pmc/articles/PMC8921940/ /pubmed/35350672 http://dx.doi.org/10.1159/000521538 Text en Copyright © 2022 by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Single Case
Imai, Jin
Ichikawa, Hitoshi
Kaneko, Motoki
Ito, Hiroyuki
Takashimizu, Shinji
Shirai, Takayuki
Tajiri, Takuma
Watanabe, Norihito
Suzuki, Hidekazu
Primary Sclerosing Cholangitis Complicated with Aphthoid Colitis Difficult to Diagnose from IgG4-Related Sclerosing Cholangitis
title Primary Sclerosing Cholangitis Complicated with Aphthoid Colitis Difficult to Diagnose from IgG4-Related Sclerosing Cholangitis
title_full Primary Sclerosing Cholangitis Complicated with Aphthoid Colitis Difficult to Diagnose from IgG4-Related Sclerosing Cholangitis
title_fullStr Primary Sclerosing Cholangitis Complicated with Aphthoid Colitis Difficult to Diagnose from IgG4-Related Sclerosing Cholangitis
title_full_unstemmed Primary Sclerosing Cholangitis Complicated with Aphthoid Colitis Difficult to Diagnose from IgG4-Related Sclerosing Cholangitis
title_short Primary Sclerosing Cholangitis Complicated with Aphthoid Colitis Difficult to Diagnose from IgG4-Related Sclerosing Cholangitis
title_sort primary sclerosing cholangitis complicated with aphthoid colitis difficult to diagnose from igg4-related sclerosing cholangitis
topic Single Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921940/
https://www.ncbi.nlm.nih.gov/pubmed/35350672
http://dx.doi.org/10.1159/000521538
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