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MOG Antibody-Associated Disorders Following SARS-CoV-2 Vaccination: A Case Report and Literature Review
Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disorder (MOGAD) is a newly identified autoimmune demyelinating disorder that is often associated with acute disseminated encephalomyelitis and usually occurs postinfection or postvaccination. Here we report a case of MOGAD after mRNA sev...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922017/ https://www.ncbi.nlm.nih.gov/pubmed/35299613 http://dx.doi.org/10.3389/fneur.2022.845755 |
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author | Matsumoto, Yuki Ohyama, Ayane Kubota, Takafumi Ikeda, Kensuke Kaneko, Kimihiko Takai, Yoshiki Warita, Hitoshi Takahashi, Toshiyuki Misu, Tatsuro Aoki, Masashi |
author_facet | Matsumoto, Yuki Ohyama, Ayane Kubota, Takafumi Ikeda, Kensuke Kaneko, Kimihiko Takai, Yoshiki Warita, Hitoshi Takahashi, Toshiyuki Misu, Tatsuro Aoki, Masashi |
author_sort | Matsumoto, Yuki |
collection | PubMed |
description | Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disorder (MOGAD) is a newly identified autoimmune demyelinating disorder that is often associated with acute disseminated encephalomyelitis and usually occurs postinfection or postvaccination. Here we report a case of MOGAD after mRNA severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. A previously healthy 68-year-old woman presented to our department with gradually worsening numbness on the right side of her face, which began 14 days after her second dose of an mRNA-1273 vaccination. The patient's brain MRI revealed a right cerebellar peduncle lesion with gadolinium enhancement, a typical finding of MOGAD. A neurological examination revealed paresthesia on her right V2 and V3 areas. Other neurological examinations were unremarkable. Laboratory workups were positive for serum MOG-IgG as assessed by live cell-based assays and the presence of oligoclonal bands in the cerebrospinal fluid (CSF). The patient's serum test results for cytoplasmic-antineutrophil cytoplasmic antibodies, perinuclear-cytoplasmic-antineutrophil cytoplasmic antibodies, GQ1b-antibodies, and aquaporin-4 antibodies (AQP4-IgG) were all negative. Tests for soluble interleukin (IL)-2 receptors in the serum, IL-6 in the CSF and skin pricks, and angiotensin converting enzyme tests were all unremarkable. The patient was diagnosed with MOGAD after receiving an mRNA SARS-CoV-2 vaccination. After two courses of intravenous methylprednisolone treatment, the patient's symptoms improved and her cerebellar peduncle lesion shrunk slightly without gadolinium enhancement. To date, there have only been two cases of monophasic MOGAD following SARS-CoV-2 vaccination, including both the ChAdOx1 nCOV-19 and mRNA-1273 vaccines, and the prognosis is generally similar to other typical MOGAD cases. Although the appearance of MOG antibodies is relatively rare in post-COVID-19–vaccine demyelinating diseases, MOGAD should be considered in patients with central nervous system (CNS) demyelinating diseases after receiving a SARS-CoV-2 vaccine. |
format | Online Article Text |
id | pubmed-8922017 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89220172022-03-16 MOG Antibody-Associated Disorders Following SARS-CoV-2 Vaccination: A Case Report and Literature Review Matsumoto, Yuki Ohyama, Ayane Kubota, Takafumi Ikeda, Kensuke Kaneko, Kimihiko Takai, Yoshiki Warita, Hitoshi Takahashi, Toshiyuki Misu, Tatsuro Aoki, Masashi Front Neurol Neurology Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disorder (MOGAD) is a newly identified autoimmune demyelinating disorder that is often associated with acute disseminated encephalomyelitis and usually occurs postinfection or postvaccination. Here we report a case of MOGAD after mRNA severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. A previously healthy 68-year-old woman presented to our department with gradually worsening numbness on the right side of her face, which began 14 days after her second dose of an mRNA-1273 vaccination. The patient's brain MRI revealed a right cerebellar peduncle lesion with gadolinium enhancement, a typical finding of MOGAD. A neurological examination revealed paresthesia on her right V2 and V3 areas. Other neurological examinations were unremarkable. Laboratory workups were positive for serum MOG-IgG as assessed by live cell-based assays and the presence of oligoclonal bands in the cerebrospinal fluid (CSF). The patient's serum test results for cytoplasmic-antineutrophil cytoplasmic antibodies, perinuclear-cytoplasmic-antineutrophil cytoplasmic antibodies, GQ1b-antibodies, and aquaporin-4 antibodies (AQP4-IgG) were all negative. Tests for soluble interleukin (IL)-2 receptors in the serum, IL-6 in the CSF and skin pricks, and angiotensin converting enzyme tests were all unremarkable. The patient was diagnosed with MOGAD after receiving an mRNA SARS-CoV-2 vaccination. After two courses of intravenous methylprednisolone treatment, the patient's symptoms improved and her cerebellar peduncle lesion shrunk slightly without gadolinium enhancement. To date, there have only been two cases of monophasic MOGAD following SARS-CoV-2 vaccination, including both the ChAdOx1 nCOV-19 and mRNA-1273 vaccines, and the prognosis is generally similar to other typical MOGAD cases. Although the appearance of MOG antibodies is relatively rare in post-COVID-19–vaccine demyelinating diseases, MOGAD should be considered in patients with central nervous system (CNS) demyelinating diseases after receiving a SARS-CoV-2 vaccine. Frontiers Media S.A. 2022-03-01 /pmc/articles/PMC8922017/ /pubmed/35299613 http://dx.doi.org/10.3389/fneur.2022.845755 Text en Copyright © 2022 Matsumoto, Ohyama, Kubota, Ikeda, Kaneko, Takai, Warita, Takahashi, Misu and Aoki. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Matsumoto, Yuki Ohyama, Ayane Kubota, Takafumi Ikeda, Kensuke Kaneko, Kimihiko Takai, Yoshiki Warita, Hitoshi Takahashi, Toshiyuki Misu, Tatsuro Aoki, Masashi MOG Antibody-Associated Disorders Following SARS-CoV-2 Vaccination: A Case Report and Literature Review |
title | MOG Antibody-Associated Disorders Following SARS-CoV-2 Vaccination: A Case Report and Literature Review |
title_full | MOG Antibody-Associated Disorders Following SARS-CoV-2 Vaccination: A Case Report and Literature Review |
title_fullStr | MOG Antibody-Associated Disorders Following SARS-CoV-2 Vaccination: A Case Report and Literature Review |
title_full_unstemmed | MOG Antibody-Associated Disorders Following SARS-CoV-2 Vaccination: A Case Report and Literature Review |
title_short | MOG Antibody-Associated Disorders Following SARS-CoV-2 Vaccination: A Case Report and Literature Review |
title_sort | mog antibody-associated disorders following sars-cov-2 vaccination: a case report and literature review |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922017/ https://www.ncbi.nlm.nih.gov/pubmed/35299613 http://dx.doi.org/10.3389/fneur.2022.845755 |
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