Cargando…
The schizophrenia risk gene Map2k7 regulates responding in a novel contingency-shifting rodent touchscreen gambling task
In schizophrenia, subjects show reduced ability to evaluate and update risk/reward contingencies, showing correspondingly suboptimal performance in the Iowa gambling task. JNK signalling gene variants are associated with schizophrenia risk, and JNK modulates aspects of cognition. We therefore studie...
Autores principales: | Openshaw, Rebecca L., Pratt, Judith A., Morris, Brian J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922023/ https://www.ncbi.nlm.nih.gov/pubmed/35275161 http://dx.doi.org/10.1242/dmm.049310 |
Ejemplares similares
-
Map2k7 Haploinsufficiency Induces Brain Imaging Endophenotypes and Behavioral Phenotypes Relevant to Schizophrenia
por: Openshaw, Rebecca L, et al.
Publicado: (2020) -
A Novel Three-Choice Touchscreen Task to Examine Spatial Attention and Orienting Responses in Rodents
por: Haddad, Faraj L., et al.
Publicado: (2021) -
Vortioxetine ameliorates anhedonic-like behaviour and promotes strategic cognitive performance in a rodent touchscreen task
por: Martis, Lena-Sophie, et al.
Publicado: (2021) -
Contingency Learning in Alcohol Dependence and Pathological Gambling: Learning and Unlearning Reward Contingencies
por: Vanes, Lucy D, et al.
Publicado: (2014) -
Mice haploinsufficient for Map2k7, a gene involved in neurodevelopment and risk for schizophrenia, show impaired attention, a vigilance decrement deficit and unstable cognitive processing in an attentional task: impact of minocycline
por: Openshaw, R.L., et al.
Publicado: (2016)