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The Features of BRCA1 and BRCA2 Germline Mutations in Hakka Ovarian Cancer Patients: BRCA1 C.536 A>T Maybe a Founder Mutation in This Population

OBJECTIVE: To investigate the frequencies of BRCA1 and BRCA2 mutations in Chinese Hakka patients with ovarian cancer. METHODS: The protein coding regions and exon intron boundary regions of the BRCA gene were sequenced using genomic DNA isolated from the lymphocytes of patients with next-generation...

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Detalles Bibliográficos
Autores principales:	Luo, Yu, Wu, Heming, Huang, Qingyan, Rao, Hui, Yu, Zhikang, Zhong, Zhixiong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922037/ https://www.ncbi.nlm.nih.gov/pubmed/35300142 http://dx.doi.org/10.2147/IJGM.S355755

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