Pulmonary Tc(99m)-PSMA uptake in asymptomatic COVID-19 patient: incidental finding in SPECT/CT study

BACKGROUND: As there are comparative studies between (68)Ga-PSMA and (99m)Tc-PSMA and spectrum of PSMA expression, this is the first case report that notifies distribution of (99m)Tc-PSMA on COVID-19 pneumonia era on the literature. Case presentation An asymptomatic 70-Y-old male who is known case of prostate adenocarcinoma underwent initial staging. SPECT/CT of the chest region reveals bilateral peripheral multifocal ground glass opacities which shows (99m)Tc-PSMA uptake. Diagnosis of corona virus was confirmed by positive RT-PCR. DISCUSSION: Unexclusive role of radiotracers in nuclear medicine has an importance for wide range of applications. Comparison between (68)Ga-PSMA and (99m)Tc-PSMA in detection of metastatic disease in prostate cancer is also under evaluation. CONCLUSIONS: This case implicates possible role of PSMA imaging in inflammation/infection process as well as necessity for lung review in hybrid imaging especially during this recent pandemic.