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Pyruvate Facilitates FACT‐Mediated γH2AX Loading to Chromatin and Promotes the Radiation Resistance of Glioblastoma

DNA repair confers the resistance of tumor cells to DNA‐damaging anticancer therapies, while how reprogrammed metabolism in tumor cells contributes to such process remains poorly understood. Pyruvate kinase M2 isoform (PKM2) catalyzes the conversion of phosphoenolpyruvate to pyruvate and regulates t...

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Detalles Bibliográficos
Autores principales:	Wu, Siyang, Cao, Ruixiu, Tao, Bangbao, Wu, Ping, Peng, Chao, Gao, Hong, Liang, Ji, Yang, Weiwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922107/ https://www.ncbi.nlm.nih.gov/pubmed/35048565 http://dx.doi.org/10.1002/advs.202104055

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