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Association Between Selected Single Nucleotide Polymorphisms in Globin and Related Genes and Response to Hydroxyurea Therapy in Ghanaian Children with Sickle Cell Disease

BACKGROUND: Sickle cell disease (SCD) is a group of genetic disorders affecting the structure and function of haemoglobin. Hydroxyurea (HU) stimulates fetal haemoglobin (HbF) and reduces sickle erythrocyte-endothelial cell interaction. However, the degree of HbF response to HU varies, with HbF expre...

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Detalles Bibliográficos
Autores principales:	Manu, Gloria Pokuaa, Segbefia, Catherine, N’guessan, Benoit Banga, Coffie, Shadrack Asiedu, Adjei, George Obeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922234/ https://www.ncbi.nlm.nih.gov/pubmed/35300055 http://dx.doi.org/10.2147/PGPM.S351599

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